Controlled delivery of intermittent stress augmentation pacing for cardioprotective effect
First Claim
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1. A cardiac rhythm management device, comprising:
- a pulse generator for incorporation into a pacing channel for delivering pacing pulses to a selected ventricular myocardial site;
a controller for controlling the delivery of pacing pulses in accordance with a programmed pacing mode;
wherein the controller is programmed to switch from a normal operating mode to a stress augmentation mode in which a particular region or regions of the ventricular myocardium are subjected to increased mechanical stress as compared with the stress experienced by those regions during the normal operating mode; and
,wherein the controller is programmed to switch to the stress augmentation mode upon expiration of a timer and to cease operating in the stress augmentation mode upon expiration of a specified time period; and
,wherein the controller is programmed to adjust one or more escape intervals when switching to the stress augmentation to increase the frequency of pacing.
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Abstract
A device and method for delivering electrical stimulation to the heart in a manner which provides a protective effect against subsequent ischemia is disclosed. The protective effect is produced by configuring a cardiac pacing device to intermittently switch from a normal operating mode to a stress augmentation mode in which the spatial pattern of depolarization is varied to thereby subject a particular region or regions of the ventricular myocardium to increased mechanical stress.
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Citations
20 Claims
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1. A cardiac rhythm management device, comprising:
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a pulse generator for incorporation into a pacing channel for delivering pacing pulses to a selected ventricular myocardial site; a controller for controlling the delivery of pacing pulses in accordance with a programmed pacing mode; wherein the controller is programmed to switch from a normal operating mode to a stress augmentation mode in which a particular region or regions of the ventricular myocardium are subjected to increased mechanical stress as compared with the stress experienced by those regions during the normal operating mode; and
,wherein the controller is programmed to switch to the stress augmentation mode upon expiration of a timer and to cease operating in the stress augmentation mode upon expiration of a specified time period; and
,wherein the controller is programmed to adjust one or more escape intervals when switching to the stress augmentation to increase the frequency of pacing. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A device for operating a cardiac rhythm management device, comprising:
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a pulse generator for incorporation into a pacing channel for delivering pacing pulses to a selected ventricular myocardial site; a controller for controlling the delivery of pacing pulses in accordance with a programmed pacing mode; a sensor for sensing a patient'"'"'s posture; wherein the controller is programmed to switch from a normal operating mode to a stress augmentation mode in which a particular region or regions of the ventricular myocardium are subjected to increased mechanical stress as compared with the stress experienced by those regions during the normal operating mode; and
,wherein the controller is programmed to switch to the stress augmentation mode upon receiving a signal from the posture sensor indicating that the patient'"'"'s posture has changed from a supine position to an erect or sitting position and to cease operating in the stress augmentation mode upon expiration of a specified time period. - View Dependent Claims (8, 9, 10, 11, 12, 13)
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14. A device for operating a cardiac rhythm management device, comprising:
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a pulse generator for incorporation into a pacing channel for delivering pacing pulses to a selected ventricular myocardial site; a sensing amplifier for incorporation into a sensing channel for detecting cardiac activity; a controller for controlling the delivery of pacing pulses in accordance with a programmed pacing mode; wherein the controller is programmed to determine an LF/HF ratio by analyzing data received from the sensing channel; wherein the controller is programmed to switch from a normal operating mode to a stress augmentation mode in which a particular region or regions of the ventricular myocardium are subjected to increased mechanical stress as compared with the stress experienced by those regions during the normal operating mode; and
,wherein the controller is programmed to switch to the stress augmentation mode when the LF/HF ratio is above a specified threshold value and to cease operating in the stress augmentation mode upon expiration of a specified time period. - View Dependent Claims (15, 16, 17, 18, 19, 20)
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Specification