Inducing neurogenesis within a human brain
First Claim
1. A method for inducing neurogenesis in a brain of a human to treat Alzheimer'"'"'s Disease or mild cognitive impairment (MCI) by means of an implantable signal generator and a lead having a proximal end coupled to the signal generator and a distal portion having at least one electrode, the method comprising:
- A) selecting a patient suffering from Alzheimer'"'"'s Disease or mild cognitive impairment (MCI);
implanting the at least one electrode in an anterior thalamic nuclei complex of the Papez circuit of the patient;
C) coupling the proximal end of the implanted electrode to the sign generator; and
D) operating the signal generator to deliver high frequency stimulation of about 50 to about 200 Hz to the anterior thalamic nuclei complex to cause a production of new or replacement neurons in a second portion of the Papez circuit, including at least a hippocampus.
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Accused Products
Abstract
Methods and apparatus for inducing neurogenesis within a human. An implantable signal generator is used to deliver high frequency stimulation to deep brain tissue elements. The implanted device delivers treatment therapy to the brain to thereby induce neurogenesis by the human. A sensor may be used to detect various symptoms of nervous system discovery. A microprocessor algorithm may then analyze the output from the sensor to regulate the stimulation and/or drug therapy delivered to the brain.
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Citations
18 Claims
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1. A method for inducing neurogenesis in a brain of a human to treat Alzheimer'"'"'s Disease or mild cognitive impairment (MCI) by means of an implantable signal generator and a lead having a proximal end coupled to the signal generator and a distal portion having at least one electrode, the method comprising:
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A) selecting a patient suffering from Alzheimer'"'"'s Disease or mild cognitive impairment (MCI); implanting the at least one electrode in an anterior thalamic nuclei complex of the Papez circuit of the patient; C) coupling the proximal end of the implanted electrode to the sign generator; and D) operating the signal generator to deliver high frequency stimulation of about 50 to about 200 Hz to the anterior thalamic nuclei complex to cause a production of new or replacement neurons in a second portion of the Papez circuit, including at least a hippocampus. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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Specification