Array stimulator

• US 8,612,018 B2
• Filed: 05/20/2008
• Issued: 12/17/2013
• Est. Priority Date: 05/22/2007
• Status: Active Grant

• Current Assignee: Bioinduction Limited
• Original Assignee: Ivor Stephen Gillbe
• Inventors: Gillbe, Ivor Stephen
• Primary Examiner(s): Koharski, Christopher D
• Assistant Examiner(s): KIMBALL, JEREMIAH T
• Application Number:
  US12/601,036
• Publication Number:
  US 20100152817A1
• Time in Patent Office: 2,037 Days
• Field of Search: 607/72, 607/67, 607/70, 607/117
• US Class Current: 607/72
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/0553 Paddle shaped electrodes, e.g. for laminotomy
• CPC Class Codes: A61N 1/36017 with leads or electrodes penetrating the skin
• CPC Class Codes: A61N 1/36021 for treatment of pain
• CPC Class Codes: A61N 1/36071 Pain

Abstract

An array stimulator has a plurality of electrodes in an array, the electrodes forming a plurality of electrode pairs, and a signal generator for generating signals to the electrodes so as to generate electrical pulse in a patient to which the stimulator has been applied either transcutaneously or by implantation. Those electrical pulses form a composite pulse in the patient which stimulates the nervous system of the patient. The composite pulse has a duration between 4 μs and 1500 μs and a maximum voltage between 2V and 50V when the stimulator is implanted, and 15V to 500V when applied transcutaneously. The electrical pulses themselves are significantly shorter duration than the composite pulse, so they stimulate the nervous system of the patient much less than the composite pulse or not at all.

Claims

1. An apparatus for applying electrical pulses to a patient, the apparatus being implantable in the patient, the apparatus comprising a plurality of electrodes arranged in an array, the electrodes forming a plurality of electrode pairs wherein each pair comprises an anode and a cathode which are made up of one or more electrodes from the array electrically connected in parallel, and a signal generator for generating signals to said electrodes so as to form said electrical pulses, the signal generator being arranged to generate said signals such that the signals are either sequentially transmitted to successive electrode pairs in a cycle so the respective electrode pairs receive the corresponding signals at different times, or alternatively so that the signals are received by the electrode pairs such that they do not all start and end at the same point in time, wherein said electrical pulses form by addition a composite pulse which has a duration between 4 μ

s and 1500 μ

s and a maximum voltage between 2 v and 50 v, wherein the composite pulse comprises a plurality of said electrical pulses having a first polarity, and a subsequent plurality of said electrical pulses having a second polarity opposite to the first polarity.

2. An apparatus according to claim 1, wherein the signal generator is arranged to generate said signals such that, throughout the duration of said composite pulse, successive electrode pairs receive the corresponding signals.

3. An apparatus according to claim 1, wherein the signal generator is arranged to generate said signals such that there are gaps between said signals of a duration not greater than 200 μ

s during said composite pulse.

4. An apparatus according to claim 1, wherein said signal generator is arranged to generate said signals such that said signals are each pulse trains with a minimum pulse width of 0.1 μ

s and a maximum pulse width of 50 μ

s.

5. An apparatus according to claim 1, wherein said composite pulse has a duration between 20 μ

s and 1000 μ

s.

6. An apparatus according to claim 1, wherein said signal generator has a housing forming one of said electrodes.

7. An apparatus according to claim 1, wherein said signal generator has a plurality of signal generation devices, each signal generation device being associated with a corresponding one of said plurality of electrodes.

8. An apparatus according to claim 1, wherein said signal generator has at least one signal generation device and a network of high speed switching elements, the network of switching elements being arranged to direct the output of said at least one generation device to said electrode pairs.

9. An apparatus according to claim 1, wherein the signal generator is arranged to generate said signals such that said composite pulse has a notional pulse width and a notional voltage, current or charge, and which is arranged to generate a stimulation field of a desired location and area in the patient.

10. An apparatus according to claim 9, wherein said signal generator is arranged to control the relative duty signals of said signals, so as to vary said desired location and/area.

11. An apparatus according to claim 10, wherein said signal generator is further arranged to control the number, distribution and/or configuration of electrode pairs receiving said corresponding signals.

12. An apparatus according to claim 10, having an operator interface for controlling said signal generator so as to vary said desired location and/area.

13. An apparatus according to claim 1, wherein each of the said signals comprises a plurality of sub-components.

14. An apparatus according to claim 13, where the signal generator is arranged to separate said sub-components such that there are gaps between said sub-components and further gaps between said electrical pulses, said gaps and said further gaps each having a duration not greater than 200 μ

s, and the sum of the durations of said subcomponents, excluding said gaps and said further gaps, equal to the duration of said composite pulse.

15. An apparatus according to claim 1, wherein said signal generator is arranged to generate said signals such that said electrical pulses have a maximum pulse width of 10 μ

s.

16. An apparatus according to claim 14, wherein said electrical pulses have a maximum pulse width of 2 μ

s.

17. An apparatus according to claim 1, wherein said composite pulse has a duration between 20 μ

s and 1000 μ

s.

18. An apparatus according to claim 1, wherein the signal generator includes a power supply, a controller arranged to generate a composite signal corresponding to said composite pulse, and a converter arranged to convert the composite signal into said signals using a network of high speed switching elements.

19. An apparatus according to claim 1, wherein the signal generator includes a power supply, a controller storing data representing said composite pulse, and a network of high speed switching elements, the controller being arranged to control the power supply and said switching elements so as to generate said signals.

20. An apparatus according to claim 1, having a controller arranged to control, represent or store a desired notional voltage, current, charge or energy distribution in a mathematical or empirically derived model of human or animal tissue in the region of the array, and said signal generator includes a transformation element arranged to reduce said notional voltage, current charge or energy distribution into said signals and a stimulator arranged to send said signals to the array of electrodes, said stimulator being arranged to transmit said signals sequentially to said electrodes at different times such that successive electrode pairs are arranged to generate said pulses in a cycle, or to transmit said signals so that said pulses do not all start and end at the same point in time.

21. An apparatus according to claim 20, wherein said controller includes an operator interface for selectively controlling said notional voltage, current charge or energy distribution.

22. An apparatus according to claim 1, wherein said signal generator is arranged to generate said signals such that said electrical pulses have little or no activation of afferent fibres but said composite pulse is sufficient to cause an action potential in such fibres.

23. An apparatus according to claim 1, wherein the signal generator is arranged to generate said signals such that the relative pulse widths and plurality of said electrical pulses vary with respect to each other.

24. An apparatus according to claim 1, wherein the signal generator is arranged to generate said signals such that the relative pulse widths of said electrical pulses are determined with respect to each other to normalize the sensation at each electrode.