Electrochemical quantitative analysis system and method for the same

• US 8,613,850 B2
• Filed: 09/21/2008
• Issued: 12/24/2013
• Est. Priority Date: 09/21/2007
• Status: Active Grant

• Current Assignee: Apex Biotechnology Corporation
• Original Assignee: Apex Biotechnology Corporation
• Inventors: Lin, Yueh-Hui, Chen, Guan-Ting, Chu, Ching-Yuan, Wang, Jui-Ping, Shen, Thomas Y. S., Chen, Te-Ho, Chang, Cheng Allen
• Primary Examiner(s): Noguerola, Alex
• Application Number:
  US12/234,659
• Publication Number:
  US 20090078588A1
• Time in Patent Office: 1,920 Days
• Field of Search: 20440301-40315, 205/777.5, 205/778, 205/792
• US Class Current: 205/792
• CPC Class Codes: G01N 27/3273 Devices therefor, e.g. test element readers, circuitry details not specific to biochemical electrodes G01N33/4875
• CPC Class Codes: G01N 27/3274 Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration coding of calibration information G01N33/48771
• CPC Class Codes: G01N 33/48771 Coding of information, e.g. calibration data, lot number

Abstract

A system for electrochemical quantitative analysis is provided. The system includes a measuring apparatus having a plurality of analysis modes. Each of the analysis modes is for quantitatively analyzing different biochemical substance. The system further includes a plurality of test strips. Each of the test strips has a different identification component for a different analysis mode. When one of the plurality of test strips is selected to electronically connect to the measuring apparatus, the measuring apparatus executes one of the plurality of analysis modes according to the identification component of the selected test strip to quantitatively analyze a corresponding biochemical substance.

Claims

1. An electrochemical quantitative analysis system, comprising:

a measuring apparatus, having a plurality of analysis modes, wherein each analysis mode is for quantitatively analyzing different biochemical substance; and

a plurality of test strips, each test strip having a different identification component corresponding to each analysis mode, wherein when one of the plurality of test strips is selected to electronically connect to the measuring apparatus, the measuring apparatus executes the analysis mode according to the identification component of the test strip to quantitatively analyze a corresponding biochemical substance, and wherein each test strip comprises;

a first working electrode, for producing a first current signal in a first reaction area;

a second working electrode, for producing a second current signal in a second reaction area different from the first reaction area; and

a reference electrode, one side of the reference electrode being divided into a first part and a second part to respectively form a first reference electrode corresponding to the first reaction area and a second reference electrode corresponding to the second reaction area, and the other side of the reference electrode being divided into a reference electrode joint and a third part connected to the identification component.

2. The system according to claim 1, wherein the measuring apparatus is selectively connected to each test strip through a connector and the connector is suitable for each test strip.

3. The system according to claim 1, wherein each identification component comprises a passive device with different electrical characteristic and the measuring apparatus executes one of the plurality analysis modes according to the electrical characteristic.

4. The system according to claim 3, wherein the passive device is a transistor, an inductor, or a capacitor.

5. The system according to claim 3, wherein each passive device is a transistor formed by different pattern, thickness, size, length, or material.

6. The system according to claim 1, wherein the measuring apparatus is selectively connected to the reference electrode through the identification component.

7. The system according to claim 1, wherein one of the plurality analysis modes is built inside the measuring apparatus.

8. The system according to claim 1, wherein one of the plurality analysis modes is stored in an external card.

9. The system according to claim 1, wherein the measuring apparatus corrects a quantitative analysis result for the corresponding biochemical substance according to a difference between the first current signal and the second current signal.

10. The system according to claim 9, wherein one of the plurality test strips further comprises:

a first reaction basin on the first working electrode, the first reaction basin containing an enzyme for reacting with the corresponding biochemical substance; and

a second reaction basin on the second working electrode, wherein the second reaction basin doesn'"'"'t contain the enzyme.

11. The system according to claim 9, wherein one of the plurality of test strips further comprises a third working electrode for producing a third current signal for the correction mode.

12. The system according to claim 1, wherein each test strip further comprises a sample placement area, an observation window, and at least one vent near to the sample placement area and the observation window.

13. The system according to claim 1, wherein the electrochemical quantitative analysis system is suitable for a whole blood sample.

14. The system according to claim 1, wherein the measuring apparatus comprises a correction mode to correct a quantitative analysis result for the corresponding biochemical substance.

15. The system according to claim 14, wherein the correction mode is a temperature correction mode or a HCT % correction mode.

16. A method of utilizing the system in the claim 1 for quantitatively analyzing biochemical substances, comprising:

selecting one of the test strips to analyze the corresponding biochemical substance;

disposing a sample into the strip; and

electrically connecting the strip and the measuring apparatus, wherein the measuring apparatus executes the analysis mode according to the identification component of the strip to analyze a quantity of the corresponding biochemical substance contained in the sample.

17. The method according to claim 16, wherein the sample is a whole blood sample.

18. The method according to claim 16, wherein the test strip further comprises a third working electrode for producing a third current signal such that the measuring device can have a nonlinear correction of the quantity of the corresponding biochemical substance contained in the sample.