Drug application during a CT scan

• US 8,615,289 B2
• Filed: 02/15/2005
• Issued: 12/24/2013
• Est. Priority Date: 02/20/2004
• Status: Expired due to Fees

• Current Assignee: Koninklijke Philips Electronics N.V. (Koninklijke Philips N.V.)
• Original Assignee: Koninklijke Philips N.V.
• Inventors: Koehler, Thomas, Grass, Michael
• Primary Examiner(s): Le, Long V.
• Assistant Examiner(s): HOFFA, ANGELA MARIE
• Application Number:
  US10/598,004
• Publication Number:
  US 20080027307A1
• Time in Patent Office: 3,234 Days
• Field of Search: None
• US Class Current: 600/427
• CPC Class Codes: A61B 6/032 Transmission computed tomography [CT]
• CPC Class Codes: A61B 6/503 for diagnosis of the heart
• CPC Class Codes: A61B 6/541 involving acquisition triggered by a physiological signal
• CPC Class Codes: A61B 8/481 involving the use of contrast agent, e.g. microbubbles introduced into the bloodstream analysis of echo signal exploiting properties of a contrast enhancer in devices for short-range imaging with acoustic waves G01S7/52039

Abstract

Controlled local application of drugs to a certain part of a body of a patient may be of major importance during a cardiac CT scan. By transporting the drugs in containers which prevent an application of the drugs and by rupturing only those containers which are located in the vicinity of the part of the body of a patient to which the drugs have to be applied, a local application of the drugs may be performed. According to an exemplary embodiment of the present invention, the rupturing and therefore the application of the drugs may be triggered by a monitoring algorithm which evaluates changes in the heart beat rate of the patient. Advantageously, the method allows for a local delivery of the drugs on a fine time scale and therefore for a fast control of the heart beat rate during the CT scan.

Claims

1. A method of controlling a local application of drugs to a part of a body of a patient during a CT scan, wherein the drugs are transported in containers suitable for introduction into a bloodstream of the patient;

wherein the containers prevent an application of the drugs;

wherein a first drug is transported in a first container, wherein a second drug is transported in a second container;

wherein the first container has a first resonance frequency;

wherein the second container has a second resonance frequency; and

wherein the first resonance frequency is different from the second resonance frequency;

the method comprising the steps of;

applying the first container and the second container to the bloodstream of the patient;

monitoring a heart beat rate of the patient during the CT scan; and

selectively rupturing at least one of the first container and the second container in proximity to the part of the body on the basis of the monitored heart beat rate, resulting in a local application of at least one of the first drug and the second drug respectively to the part of the body and a controlled change of the heart beat rate of the patient to reduce variations in the heart beat rate during the CT scan.

2. The method according to claim 1, wherein the part of the body the drugs are locally applied to is the heart of the patient;

and wherein the first drug is locally applied to the heart of the patient by rupturing the first container in proximity to the heart.

3. The method according to claim 1, wherein when an ultrasonic energy pulse with a first frequency corresponding to the first resonance frequency is applied to the first container, a rupture of the first container occurs and the first drug is released from the first container;

wherein the rupturing of the first container is performed by a destruction device;

wherein the destruction device generates focused ultrasound pulses; and

wherein the ultrasound pulses have a first frequency corresponding to the first resonance frequency of the first container.

4. The method according to claim 1, wherein when an electromagnetic energy beam with a first frequency corresponding to the first resonance frequency is applied to the first container, a rupture of the first container occurs and the first drug is released from the first container;

wherein the rupturing of the first container is performed by a destruction device;

wherein the destruction device generates a beam of electromagnetic radiation; and

wherein the electromagnetic radiation has a first frequency corresponding to the first resonance frequency of the first container.

5. The method according to claim 1, wherein the application of the first drug increases the heart beat rate;

and wherein the application of the second drug decreases the heart beat rate.

6. The method according to claim 1, wherein the containers are micro-bubbles.

7. The CT scanner system according to claim 1, wherein the containers are micro-bubbles.

8. A CT scanner system adapted for controlling a local application of drugs to a part of a body of a patient during a CT scan, comprising:

a CT scanner;

a monitoring device;

a data processing device; and

a destruction device;

wherein a first drug is transported in a first container;

wherein a second drug is transported in a second container;

wherein the second drug is different from the first drug;

the first container has a first resonance frequency;

the second container has a second resonance frequency; and

wherein the first resonance frequency is different from the second resonance frequency;

wherein the drugs are transported in containers suitable for introduction into a bloodstream of the patient and preventing an application of the drugs;

wherein the CT scanner is adapted for acquisition of an image of the part of the body;

wherein the monitoring device is adapted for monitoring a heart beat rate of a heart of the patient during the CT scan;

wherein the destruction device is configured to selectively rupture at least one of the first container and the second container in proximity to the part of the body, resulting in a local application of at least one of the first drug and the second drug respectively to the part of the body and a controlled change of the heart beat rate of the patient to reduce variations in the heart beat rate during the CT scan;

and wherein the data processing device is configured to selectively trigger the rupturing of at least one of the first container and the second container on the basis of the monitored heart beat rate.

9. The CT scanner system according to claim 8, wherein the first drug is locally applied to the heart of the patient on the basis of the heart beat rate;

wherein the destruction device is adapted for generating one of focused ultrasound pulses and a beam of electromagnetic radiation; and

wherein a frequency of the one of focused ultrasound pulses and the beam of electromagnetic radiation corresponds to the first resonance frequency of the first container.

10. The CT scanner system according to claim 8, wherein the part of the body the at least one drug is locally applied to is the heart of the patient.

11. The CT scanner system according to claim 8, wherein when an ultrasonic energy pulse with a first frequency corresponding to the first resonance frequency is applied to the first container, a rupture of the first container occurs and the first drug is released from the first container;

wherein the rupturing of the first container is performed by a destruction device;

wherein the destruction device generates focused ultrasound pulses; and

wherein the ultrasound pulses have a first frequency corresponding to the first resonance frequency of the first container.

12. The CT scanner system according to claim 8, wherein when an electromagnetic energy beam with a first frequency corresponding to the first resonance frequency is applied to the first container, a rupture of the first container occurs and the first drug is released from the first container;

wherein the rupturing of the first container is performed by a destruction device;

wherein the destruction device generates a beam of electromagnetic radiation; and

wherein the electromagnetic radiation has a first frequency corresponding to the first resonance frequency of the first container.

13. The CT scanner system according to claim 8, wherein application of the first drug increases the heart beat rate, and application of the second drug decreases the heart beat rate.

14. A non-transitory computer program for controlling a local application of drugs to a part of a body of a patient during a CT scan, wherein the computer program causes a processor to perform the following operation when the computer program is executed on the processor:

evaluating a heart beat rate of a heart of the patient during the CT scan;

selectively triggering a rupturing of at least one of a first container and a second container comprising a first drug and a second drug respectively on the basis of the evaluation of the heart beat rate;

wherein the first drug is transported in the first container;

wherein the second drug is transported in the second container;

wherein the second drug is different from the first drug;

the first container has a first resonance frequency for rupturing the first container;

the second container has a second resonance frequency for rupturing the second container; and

wherein the first resonance frequency is different from the second resonance frequency;

wherein the first container is located in proximity to the part of the body, resulting in a local application of the first drug to the part of the body and a controlled change of the heart beat rate of the patient to reduce variations in the heart beat rate during the CT scan.

15. An imaging scanner system comprising:

a scanner adapted for acquiring an image of the heart in an imaging scan;

a monitoring device adapted to monitor a heart beat rate of the patient during the imaging scan;

a destruction device configured to selectively rupture at least one of a first container and a second container in proximity to the heart, resulting in a local application of at least one of a first drug and a second drug stored in the first container and the second container respectively and a controlled change of the patient'"'"'s heart beat rate to reduce variations in the heart beat rate during the imaging scan;

wherein the first drug is transported in the first container;

wherein the second drug is transported in the second container;

wherein the second drug is different from the first drug;

the first container has a first resonance frequency;

the second container has a second resonance frequency; and

wherein the first resonance frequency is different from the second resonance frequency; and

a data processing device configured to selectively trigger the destruction device, based on data received from the monitoring device.

16. The imaging scanner of claim 15 wherein the destruction device generates one of an ultrasound pulse and an electromagnetic radiation pulse in order to rupture the first container.

17. The imaging scanner of claim 16 wherein the destruction device is adapted to generate pulses having different frequencies in order to rupture containers having different resonance frequencies.