Integrated bio-reactor monitor and control system

• US 8,615,324 B2
• Filed: 07/22/2011
• Issued: 12/24/2013
• Est. Priority Date: 11/26/2003
• Status: Active Grant

• Current Assignee: New England Controls, Inc. (Enerpac Tool Group Corp.)
• Original Assignee: Broadley James Corporation
• Inventors: West, Larry Eugene
• Primary Examiner(s): BOWERS, NATHAN ANDREW
• Application Number:
  US13/188,758
• Publication Number:
  US 20120072028A1
• Time in Patent Office: 886 Days
• Field of Search: 435/289.1, 435/286.1, 435/3, 239/66, 366/102, 700/17, 700/266, 700/87, 700/9, 719/331
• US Class Current: 700/266
• CPC Class Codes: C12M 41/48 Automatic or computerized control automatic analysis G01N35/00
• CPC Class Codes: C12Q 3/00 Condition responsive control processes apparatus therefor C12M1/36; controlling or regulating in general G05
• CPC Class Codes: G05B 15/02 electric
• CPC Class Codes: G05B 19/042 using digital processors G05B19/05 takes precedence
• CPC Class Codes: G05B 2219/25425 Personal computer
• CPC Class Codes: G05D 21/02 characterised by the use of electric means

Abstract

Systems and methods for automatically controlling conditions of a process are disclosed. In one example, a controller is programmed with a sequence of steps and parameters required to carry out a bioreactor process. The controller receives information related to a condition of the process over a first communication network, determines a control signal based on the received information and the programmed process, and sends the control signal over a second communication network to a benchtop utility tower. In one example, the utility tower can include transmitters for temperature, pH, and dissolved oxygen that send information related to a condition of the process to the controller over the first communication network, and an agitation system, a gas control system, a temperature control system and a pump control system that perform a control action based on the control signal affecting the process condition. The utility tower can include a computer with a human-machine interface that communicates with the controller over a third communication network.

Claims

1. A method of electronically recording a history of a bioreactor control process, the method comprising:

monitoring a condition in a bioreactor in accordance with the bioreactor control process;

receiving, in a utility tower, sensor data related to the condition in the bioreactor, the bioreactor located external to the utility tower;

calculating information using the sensor data;

sending the information related to the sensor data from the utility tower to a controller over a first communication network;

receiving in the controller the sensor data from the utility tower;

determining, in the controller, control signals to carry out the bioreactor control process, the control signals based on at least the information received from the utility tower;

sending a first control signal from the controller to one of a gas control system and a pump control system housed in the utility tower over a second communication network to add a substance to or remove a substance from the bioreactor;

changing, in response to the first control signal communicated from the controller to the utility tower, the contents in the bioreactor by supplying a substance to the bioreactor from a supply system or removing a substance from the bioreactor;

sending a second control signal from the controller to the utility tower over the second communication network to agitate a solution in the bioreactor;

agitating the solution in the bioreactor in response to the second control signal communicated to the utility tower over the second communication network; and

recording an electronic history of the bioreactor control process performed in the bioreactor,

wherein supply or removal of the substance in the bioreactor in response to the information related to the sensor data is under the control of the first control signal from the controller to the utility tower.

2. The method of claim 1, wherein recording an electronic history includes recording the information transmitted from the utility tower to the controller over the first communication network.

3. The method of claim 2, wherein the information transmitted from the utility tower to the controller and recorded in the electronic history includes information relating to a temperature condition of the bioreactor, a pH condition of the bioreactor, a dissolved oxygen (DO) condition of the bioreactor, a glucose condition of the bioreactor, and a concentration of dissolved oxygen condition of the bioreactor.

4. The method of claim 1, wherein recording an electronic history includes logging changes in conditions in the bioreactor corresponding to control signals received in the utility tower from the controller over the second communication network.

5. The method of claim 1, wherein the electronic history includes information relating to an amount of gas added or removed from the bioreactor, a type of gas added or removed from the bioreactor, an amount of liquid substance added or removed from the bioreactor, a type of fluid added or removed from the bioreactor, a duration of agitation of contents of the bioreactor, a speed of an impeller during agitation of contents of the bioreactor, a time the addition or removal of gas started, a time the addition or removal of gas ended, a time the addition or removal of liquid substance from the bioreactor started, a time the addition or removal of liquid substance from the bioreactor ended, a time agitation started, and a time agitation ended.

6. The method of claim 1, further comprising storing the electronic history in the utility tower.

7. The method of claim 1, further comprising storing the electronic history separate from the utility tower.

8. The method of claim 1, further comprising analyzing the recorded electronic history and developing historical trending information.

9. The method of claim 8, further comprising changing the bioreactor control process using the historical trending information.

10. The method of claim 1, further comprising changing the partial pressure of the solution in the bioreactor in response to control signals communicated to the utility tower over the second communication network.

11. The method of claim 6, wherein storing the electronic history comprises storing the electronic history in a computer contained in the utility tower.

12. The method of claim 6, wherein storing the electronic history comprises storing the electronic history in a dedicated storage medium contained in the utility tower.

13. The method of claim 7, wherein storing the electronic history comprises storing the electronic history in a computer in communication with the controller.

14. The method of claim 7, wherein storing the electronic history comprises storing the electronic history in a dedicated storage medium in communication with the controller.