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Spinal fusion methods and devices

  • US 8,617,252 B2
  • Filed: 08/07/2009
  • Issued: 12/31/2013
  • Est. Priority Date: 10/24/2000
  • Status: Expired due to Term
First Claim
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1. An intervertebral fusion device comprising an osteoinductive composition for treating bone defects, the osteoinductive composition present in an amount effective to induce bone growth to form a bone mass in a location for fusing adjacent vertebrae, said composition comprising:

  • a biodegradable collagen carrier comprising a polymer matrix and pores forming a sponge matrix,bone morphogenetic protein 2 (BMP-2) entrained within the carrier, andLIM mineralization protein-1 (LMP-1) entrained within the carrier;

    wherein the bone morphogenetic protein 2 is present in an amount of 0.5 mg/ml to 4 mg/ml of the biodegradable collagen carrier,wherein the carrier further comprises calcium phosphate and has a calcium to phosphate (Ca/P) ratio of about 0.4 to about 0.6, and the carrier has a porosity of greater than 40%,wherein the osteoinductive composition is sufficient to deliver 2 mg of bone morphogenetic protein 2 to 40 mg of bone morphogenetic protein 2, andwherein the carrier is configured to be substantially impermeable to efflux of the entrained osteoinductive composition in vivo sufficiently that the formed bone mass is confined to the volume of the carrier when implanted, and wherein the carrier gradually exposes the entrained osteoinductive composition at said location as it degrades.

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