Methods of making an endovascular prosthesis using a deformable matrix

• US 8,617,448 B2
• Filed: 05/19/2008
• Issued: 12/31/2013
• Est. Priority Date: 05/17/2007
• Status: Active Grant

• Current Assignee: Cook Medical Technologies, LLC (Cook Group Incorporated)
• Original Assignee: Cook Medical Technologies, LLC (Cook Group Incorporated)
• Inventors: Sun, Jichao
• Primary Examiner(s): KENNEDY, TIMOTHY J
• Application Number:
  US12/598,249
• Publication Number:
  US 20100219562A1
• Time in Patent Office: 2,052 Days
• Field of Search: 264/313, 264/317, 264/221, 425/440, 249/61, 249/62, 249/183
• US Class Current: 264/313
• CPC Class Codes: A61L 2420/02 Methods for coating medical devices
• CPC Class Codes: A61L 2420/08 Coatings comprising two or more layers
• CPC Class Codes: A61L 31/04 Macromolecular materials
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: B05D 1/286 using a temporary backing to which the coating has been applied
• CPC Class Codes: B05D 3/12 by mechanical means
• CPC Class Codes: B05D 7/52 Two layers

Abstract

A method of making an endovascular prosthesis comprises the steps of applying a first layer of polymer to a portion of a deformable matrix, contacting a stent with the polymer to deform the matrix, applying a second layer of polymer over at least a portion of the stent and first layer, solidifying the layers of polymer to form the endovascular prosthesis, and removing the matrix.

Claims

1. A method of making an endovascular prosthesis having a desired shape comprising:

applying a first layer of polymer onto a portion of a deformable forming member;

contacting a stent with the polymer to deform the forming member;

applying a second layer of polymer over at least a portion of the stent and first layer;

solidifying the layers of polymer to form the endovascular prosthesis;

removing the forming member; and

wherein the deformable forming member exhibits plasticity during application of the polymer layers and stent.

2. The method of claim 1 further comprising pressing the stent into the deformable forming member.

3. The method of claim 1, wherein the deformable forming member comprises wax, polymer, elastomer, or shape memory alloy.

4. The method of claim 1, wherein the deformable forming member comprises a non-deformable core and a deformable surface.

5. The method of claim 1 wherein the deformable forming member is melted, dissolved, contracted, expanded, evaporated, or distended.

6. The method of claim 1, further comprising physically manipulating the endovascular prosthesis and deformable forming member to the desired shape before removing the deformable forming member.

7. The method of claim 1, further comprising pressing the stent toward the deformable forming member, physically manipulating the endovascular prosthesis and deformable forming member to the desired shape, and removing the deformable forming member.

8. The method of claim 1, wherein the first and second layers are solidified by cooling, curing, or chemical reaction.

9. A method of making an endovascular prosthesis having a desired shape comprising:

applying a first layer of polymer to a portion of a deformable forming member;

applying a graft material over at least a portion of the first layer and deformable forming member;

contacting a stent with the graft material, to deform the forming member;

applying a second layer of polymer over at least a portion of the stent and graft material;

solidifying the layers of polymer to thereby form the endovascular prosthesis;

removing the forming member; and

wherein the deformable forming member exhibits plasticity during application of the polymer layers and stent.

10. The method of claim 9 further comprising pressing the stent toward the deformable forming member.

11. The method of claim 9, wherein the deformable forming member comprises wax, polymer, elastomer, or shape memory alloy.

12. The method of claim 9, wherein the deformable forming member comprises a non-deformable core and a deformable surface layer.

13. The method of claim 9, wherein the deformable forming member is removed by undergoing a change.

14. The method of claim 13 wherein the deformable forming member is melted, dissolved, contracted, expanded, evaporated, or distended.

15. The method of claim 9, further comprising physically manipulating the stent and deformable forming member to the desired shape before removing the deformable forming member.

16. The method of claim 9, further comprising pressing the stent toward the deformable forming member, physically manipulating the endovascular prosthesis and deformable forming member to the desired shape, and removing the deformable forming member.

17. The method of claim 9, wherein the first and second layers are solidified by cooling, curing, or chemical reaction.