Adhesive tissue repair patch and collagen sheets

• US 8,617,584 B2
• Filed: 05/25/2010
• Issued: 12/31/2013
• Est. Priority Date: 12/18/1995
• Status: Expired due to Term

• Current Assignee: Angiodevice International GmbH (Angiotech Pharmaceuticals (US), Inc.)
• Original Assignee: Angiodevice International GmbH (Angiotech Pharmaceuticals (US), Inc.)
• Inventors: Sehl, Louis C., Trollsas, Olof Mikael, Wallace, Donald G., Toman, David, DeLustro, Frank A., Schroeder, Jacqueline A., Chu, George H.
• Primary Examiner(s): DICKINSON, PAUL W
• Application Number:
  US12/787,304
• Publication Number:
  US 20100233246A1
• Time in Patent Office: 1,316 Days
• Field of Search: None
• US Class Current: 424/422
• CPC Class Codes: A61F 2/0063 Implantable repair or support meshes, e.g. hernia meshes
• CPC Class Codes: A61L 24/043 Mixtures of macromolecular materials
• CPC Class Codes: A61L 24/08 Polysaccharides A61L24/043 takes precedence
• CPC Class Codes: A61L 24/102 Collagen
• CPC Class Codes: A61L 27/24 Collagen
• CPC Class Codes: A61L 27/26 Mixtures of macromolecular compounds
• CPC Class Codes: A61L 31/041 Mixtures of macromolecular compounds
• CPC Class Codes: A61L 31/044 Collagen
• CPC Class Codes: C08B 37/0075 Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
• CPC Class Codes: C08F 283/00 Macromolecular compounds obtained by polymerising monomers on to polymers provided for in subclass C08G
• CPC Class Codes: C08F 283/04 on to polycarbonamides, polyesteramides or polyimides C08F283/004 takes precedence
• CPC Class Codes: C08F 283/06 on to polyethers, polyoxymethylenes or polyacetals C08F283/004 takes precedence
• CPC Class Codes: C08G 65/329 with organic compounds
• CPC Class Codes: C08G 75/045 from mercapto compounds and unsaturated compounds
• CPC Class Codes: C08G 75/26 Polythioesters
• CPC Class Codes: C08H 1/00 Macromolecular products derived from proteins food proteins A23; glue, gelatine C09H
• CPC Class Codes: C08H 1/06 derived from horn, hoofs, hair, skin or leather
• CPC Class Codes: C08L 2666/26 Natural polymers, natural resins or derivatives thereof according to C08L1/00 - C08L5/00, C08L89/00, C08L93/00, C08L97/00 or C08L99/00
• CPC Class Codes: C08L 5/16 Cyclodextrin; Derivatives thereof
• CPC Class Codes: C08L 51/003 grafted on to macromolecular compounds obtained by reactions only involving unsaturated carbon-to-carbon bonds C08L51/04, C08L51/06 take precedence
• CPC Class Codes: C08L 53/00 : Compositions of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers
• CPC Class Codes: C08L 67/06 : Unsaturated polyesters
• CPC Class Codes: C08L 71/00 : Compositions of polyethers obtained by reactions forming an ether link in the main chain of polyacetals C08L59/00; of epoxy resins C08L63/00; of polythioether-ethers C08L81/02; of polyether-sulfones C08L81/06; Compositions of derivatives of such polymers
• CPC Class Codes: C08L 71/02 : Polyalkylene oxides
• CPC Class Codes: C08L 81/02 : Polythioethers; Polythioether-ethers
• CPC Class Codes: C08L 89/06 : derived from leather or skin , e.g. gelatin
• CPC Class Codes: C08L 91/06 : Waxes
• CPC Class Codes: C09D 167/02 : Polyesters derived from dicarboxylic acids and dihydroxy compounds C09D167/06 takes precedence
• CPC Class Codes: C09J 151/003 : grafted on to macromolecular compounds obtained by reactions only involving unsaturated carbon-to-carbon bonds C09J151/04, C09J151/06 take precedence
• CPC Class Codes: C09J 153/00 : Adhesives based on block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Adhesives based on derivatives of such polymers
• CPC Class Codes: C09J 189/06 : derived from leather or skin

Abstract

The present invention relates generally to synthetic polymer compositions that form interpenetrating polymer networks. In a preferred embodiment, the compositions comprise two multifunctionally activated synthetic polymers, along with a tensile strength enhancer. Such compositions form matrices that exhibit superior cohesive strength and in many instances can serve as adequate replacements for surgical means of attaching tissues, such as sutures, sponges and medical staples.

Claims

1. A biocompatible polymer device comprising a collagen sponge or sheet impregnated with a two-part reactive polyethylene glycol powder, wherein said reactive powder comprises a first polyethylene glycol having m nucleophilic groups and a second polyethylene glycol having n electrophilic groups, wherein the polyethylene glycol powder remains unreactive in the dry state, wherein said first polyethylene glycol is a tetra-functional thiol polyethylene glycol and said second polyethylene glycol is a tetra-functional glutaryl-succinimidyl polyethylene glycol.

2. The biocompatible polymer device according to claim 1, wherein the first polyethylene glycol having m nucleophilic groups is penta-erythritol polyethylene glycol ether tetra-thiol with a molecular weight of about 10,000 and the second polyethylene glycol having n electrophilic groups is penta-erythritol polyethylene glycol ether tetra succinimidyl-glutarate with a molecular weight of about 10,000.

3. A biocompatible polymer device according to claim 1 further comprising a tensile strength enhancer comprised of a material selected from the group consisting of polyglycolide, polylactide, polyglycolide-polylactide copolymers, glass wool, plastics, resins, and combinations thereof.

4. A biocompatible polymer device according to claim 1 further comprising an additional compound selected from the group consisting of glycosaminoglycans, proteins, and peptide fragments.

5. A biocompatible polymer device according to claim 3, wherein the additional compound is a protein selected from the group consisting of collagen, fibronectin, gelatin, albumin, or peptide fragments thereof.