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Polymers for analyte detection

  • US 8,617,819 B2
  • Filed: 09/19/2005
  • Issued: 12/31/2013
  • Est. Priority Date: 09/17/2004
  • Status: Active Grant
First Claim
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1. A method of determining a biological entity, comprising:

  • exposing a sample suspected of containing a biological entity to at least two fluorescent pi-conjugated polymers, each polymer comprising a phenylene ethynylene backbone having at least two phenylene ethynylene groups and a plurality of biological recognition elements covalently attached to the pi-conjugated polymer via the phenyl groups of the phenylene ethynylene backbone, wherein the biological recognition elements are able to specifically interact with the biological entity;

    allowing the biological entity, if present, to interact with the biological recognition elements of the at least two fluorescent pi-conjugated polymers in a manner bringing said at least two fluorescent pi-conjugated polymer into proximity with each other such that an emissive signal is produced at a threshold level;

    and determining fluorescence of the sample.

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