Laser based identification of molecular characteristics
First Claim
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1. A method of manufacturing a pharmaceutical compound, the method comprising:
- (a) emitting a laser beam;
(b) shaping the laser beam with a shaper;
(c) polarizing the laser beam;
(d) testing the pharmaceutical compound with the shaped and polarized laser beam;
(e) automatically determining a chiral property of the pharmaceutical compound based on the test;
(f) creating a substantially helical and propeller-like direction and curvature of the polarized and shaped laser beam to cause enantiomeric selectivity; and
(g) detecting a characteristic of the pharmaceutical compound with an ion trap mass spectrometer while interrogating ions in the pharmaceutical compound with phase and polarization shaped laser beam pulses.
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Abstract
Enantiomers are characterized, identified, synthesized and/or modified with a shaped laser pulse. In another aspect of the present invention, binary shaping and circular polarization are employed with a laser pulse. A further aspect of the present invention provides a quarter-wave plate in combination with one or more pulse shapers.
276 Citations
27 Claims
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1. A method of manufacturing a pharmaceutical compound, the method comprising:
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(a) emitting a laser beam; (b) shaping the laser beam with a shaper; (c) polarizing the laser beam; (d) testing the pharmaceutical compound with the shaped and polarized laser beam; (e) automatically determining a chiral property of the pharmaceutical compound based on the test; (f) creating a substantially helical and propeller-like direction and curvature of the polarized and shaped laser beam to cause enantiomeric selectivity; and (g) detecting a characteristic of the pharmaceutical compound with an ion trap mass spectrometer while interrogating ions in the pharmaceutical compound with phase and polarization shaped laser beam pulses. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A method of manufacturing a pharmaceutical product, the method comprising:
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(a) emitting a set of laser beam pulses on the pharmaceutical product, each of the pulses having a duration of less than 100 femtoseconds; (b) shaping the pulses with a shaper to control phase and amplitude in the pulses; (c) automatically detecting and compensating for distortions in the pulses, without a genetic learning algorithm; (d) polarizing the pulses after step (b) to control the electric field direction therein; (e) detecting or changing a characteristic of the pharmaceutical product with the shaped and polarized pulses; and (f) detecting a characteristic of the pharmaceutical product with an ion trap mass spectrometer while interrogating ions in the pharmaceutical product with phase and polarization shaped laser beam pulses. - View Dependent Claims (10, 11, 12, 13, 14, 15)
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16. A method of operating a laser system, the method comprising:
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(a) emitting a laser beam pulse on a pharmaceutical compound; (b) minimizing phase distortions of the pulse by pulse shaping without a genetic learning algorithm; (c) polarization shaping of the pulse after step (b); and (d) detecting a characteristic of a pharmaceutical compound with an ion trap mass spectrometer while interrogating ions in the pharmaceutical compound with phase and polarization shaped laser beam pulses. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
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Specification