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Laser based identification of molecular characteristics

  • US 8,618,470 B2
  • Filed: 11/29/2006
  • Issued: 12/31/2013
  • Est. Priority Date: 11/30/2005
  • Status: Active Grant
First Claim
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1. A method of manufacturing a pharmaceutical compound, the method comprising:

  • (a) emitting a laser beam;

    (b) shaping the laser beam with a shaper;

    (c) polarizing the laser beam;

    (d) testing the pharmaceutical compound with the shaped and polarized laser beam;

    (e) automatically determining a chiral property of the pharmaceutical compound based on the test;

    (f) creating a substantially helical and propeller-like direction and curvature of the polarized and shaped laser beam to cause enantiomeric selectivity; and

    (g) detecting a characteristic of the pharmaceutical compound with an ion trap mass spectrometer while interrogating ions in the pharmaceutical compound with phase and polarization shaped laser beam pulses.

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