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Methods and systems for three dimensional optical imaging, sensing, particle localization and manipulation

  • US 8,620,065 B2
  • Filed: 04/11/2011
  • Issued: 12/31/2013
  • Est. Priority Date: 04/09/2010
  • Status: Active Grant
First Claim
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1. A method for locating an object in three-dimensions with an optical system, the method comprising:

  • generating one or more 3D point spread functions (PSF) by control of an associated pupil function of the optical system;

    generating one or more experimental images of the object using the one or more 3D PSF of the optical system; and

    generating a 3D position of the object by increasing a probability of matching the experimental image to the PSF in the presence of noise either with a maximum likelihood estimator or with a phase retrieval (PR) enabled maximum likelihood estimator.

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