Method and apparatus for determining an analyte concentration in a sample having interferents
First Claim
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1. A method for estimating the concentration of an analyte in a fluid sample, the method comprising:
- drawing a fluid sample into an automated monitoring system connected to a patient;
using the system to separate a first interferent from the fluid sample, the remainder comprising a fluid analysis sample;
performing a measurement of the fluid analysis sample;
identifying, based on the measurement of the fluid analysis sample, a second interferent to the estimation of the analyte, the second interferent located in the fluid analysis sample;
calculating a calibration constant which reduces error attributable to the second interferent, the calibration constant based at least partly on the measurement of the fluid analysis sample identifying the second interferent;
applying the calibration constant to the measurement; and
estimating, based on the calibrated measurement, the analyte concentration in the fluid analysis sample.
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Abstract
A method and apparatus are described that permit an analyte concentration to be estimated from a measurement in the presence of compounds that interfere with the measurement. The method reduces the error in the analyte concentration in the presence of interferents. The method includes the use of a set of measurements obtained for a large population having a range of known analyte and interfering compound concentrations. From a sample measurement, which may or may not be one of the population, likely present interferents are identified, and a calibration vector is calculated.
75 Citations
27 Claims
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1. A method for estimating the concentration of an analyte in a fluid sample, the method comprising:
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drawing a fluid sample into an automated monitoring system connected to a patient; using the system to separate a first interferent from the fluid sample, the remainder comprising a fluid analysis sample; performing a measurement of the fluid analysis sample; identifying, based on the measurement of the fluid analysis sample, a second interferent to the estimation of the analyte, the second interferent located in the fluid analysis sample; calculating a calibration constant which reduces error attributable to the second interferent, the calibration constant based at least partly on the measurement of the fluid analysis sample identifying the second interferent; applying the calibration constant to the measurement; and estimating, based on the calibrated measurement, the analyte concentration in the fluid analysis sample. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A system for estimating the concentration of an analyte in a sample, the system comprising:
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a fluid network configured to connect to a patient and draw fluid samples therefrom; a separating apparatus configured to receive the fluid sample and separate a first interferent from the sample, the remainder comprising an analysis sample; an apparatus configured to perform a measurement of the analysis sample; an identifying apparatus configured to identify, based on the measurement of the analysis sample, a second interferent to the estimation of the analyte in the sample, the second interferent located in the analysis sample; a calibration processor configured to calculate a calibration constant which reduces error attributable to the second interferent, the calibration constant based at least partly on the measurement of the fluid analysis sample identifying the second interferent; the calibration processor further configured to apply the calibration constant to the measurement; and an estimating apparatus configured to estimate, based on the calibrated measurement, the analyte concentration in the sample. - View Dependent Claims (11, 12, 13, 14, 15)
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16. An analyte detection system comprising:
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a fluid network configured to be connected to a patient and receive periodic sample withdrawals therefrom; a separator for separating a first interferent from a sample to provide an analysis sample; a sensor configured to provide information relating to a measurement of an analyte in the analysis sample; a processor; and a computer storage medium having stored program instructions executable by the processor such that the system is configured to; identify, based on the measurement of the analysis sample after the first interferent has been separated, a second interferent to the estimation of the analyte in the sample; calculate, based on the identified second interferent, a calibration which reduces error attributable to the second interferent, the calibration comprising determining a calibration constant; apply the calibration to the measurement; and estimate, based on the calibrated measurement, the analyte concentration in the sample. - View Dependent Claims (17, 18, 19, 20)
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21. A method for determining a concentration of an analyte in a portion of a fluid sample from a patient, the method comprising:
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providing a fluid handling system in fluid communication with a fluid source in a patient, the fluid handling system configured to draw a plurality of fluid samples while in continuous fluid communication with the fluid source in the patient, said plurality of fluid samples comprising at least a first fluid sample and a second fluid sample, the second fluid sample drawn after the first fluid sample; drawing, via the fluid handling system, the first fluid sample from the patient, the first fluid sample comprising blood or a component of blood; transporting, via the fluid handling system, a portion of the first fluid sample to an analysis system; removing a first interference from the first fluid sample; identifying based on a measurement of the first fluid sample, a second interference to a determination of a concentration of an analyte in the first fluid sample, the second interference located in the first fluid sample; correcting for the second interference by using the measurement of the first fluid sample to calculate a calibration constant; applying the calibration constant to the measurement; wherein the fluid handling system is configured to remain in fluid communication with the fluid source in the patient during said drawing, said transporting, and said correcting, and wherein said correcting occurs before drawing the second fluid sample from the fluid source in the patient. - View Dependent Claims (22, 23, 24, 25, 26, 27)
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Specification