System and method for ischemia classification with implantable medical device

• US 8,620,416 B2
• Filed: 01/18/2011
• Issued: 12/31/2013
• Est. Priority Date: 01/31/2007
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Song, Zhendong, Lu, Steven N., Musley, Shailesh K. V., Warman, Eduardo N.
• Primary Examiner(s): MALAMUD, DEBORAH LESLIE
• Application Number:
  US13/008,607
• Publication Number:
  US 20110112422A1
• Time in Patent Office: 1,078 Days
• Field of Search: 600508-509, 600/521, 128/920, 128/923
• US Class Current: 600/521
• CPC Class Codes: A61B 5/349 Detecting specific parameters of the electrocardiograph cycle
• CPC Class Codes: A61B 5/7264 Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems neural networks per se G06N3/00; expert systems per se G06N5/00
• CPC Class Codes: G16H 50/20 for computer-aided diagnosis, e.g. based on medical expert systems
• CPC Class Codes: Y10S 128/92 Computer assisted medical diagnostics
• CPC Class Codes: Y10S 128/923 by comparison of patient data to other data

Abstract

An implantable medical device monitors ST segment data collected from EGM. ST trends are established and monitored over time. The IMD is able to discern whether the data indicate supply ischemia, demand ischemia, or other physiological causes. The IMD is then able to provide appropriate information and alerts.

Claims

1. A method comprising:

obtaining an electrogram representing cardiac data from an implantable medical device for a plurality of cardiac cycles;

determining an ST segment data point for each of the cardiac cycles;

initiating a timer interval when one of the ST segment data points exceeds a threshold value;

calculating a slope between two of the ST segment data points that occur during the timer interval; and

determining whether the ST segment data points indicate ischemia based on the calculated slope.

2. The method of claim 1, further comprising determining that the ST segment data points do not indicate supply ischemia if the calculated slope is less than a first slope value.

3. The method of claim 1, further comprising determining that the ST segment data points indicate demand ischemia if the calculated slope is less than a first slope value.

4. The method of claim 1, wherein the two of the ST segment data points are separated by a plurality of the ST segment data points.

5. The method of claim 1, further comprising determining a maximum ST segment data point value during the timer interval, wherein the two of the ST segment data points include the maximum ST segment data point value.

6. The method of claim 1, further comprising determining a maximum ST segment data point value during the timer interval, wherein the two of the ST segment data points occur prior to the maximum ST segment data point value.

7. The method of claim 1, further comprising:

determining a maximum ST segment data point value during the timer interval;

determining an amount of time from initiation of the timer interval until the maximum ST segment data point value occurs; and

determining whether the ST segment data points indicate ischemia based on the amount of time.

8. The method of claim 7, further comprising determining that the ST segment data points do not indicate supply ischemia if the amount of time is less than a first short value or greater than a first long value.

9. The method of claim 7, further comprising determining that the ST segment data points do not indicate supply ischemia if an ST segment data point occurring at a termination of the timer interval is less than a predetermined percentage of the maximum ST segment data point value.

10. The method of claim 1, wherein determining an ST segment data point further comprises:

identifying a peak of an R wave;

adding a predetermined time interval to the identified peak; and

identifying a recorded value at a time identified by the predetermined time interval after the peak of the R wave as the ST segment data point.

11. The method of claim 10, further comprising:

determining a PR isoelectric baseline value; and

subtracting the PR isoelectric baseline value from the recorded value to identify the ST segment data point.

12. The method of claim 1, further comprising determining that the ST segment data points do not indicate supply ischemia if less than a predetermined percentage of the ST segment data points occurring during the timer interval exceed the threshold value.

13. An apparatus comprising:

means for obtaining an electrogram representing cardiac data from an implantable medical device for a plurality of cardiac cycles;

means for determining an ST segment data point for each of the cardiac cycles;

means for initiating a timer interval when one of the ST segment data points exceeds a threshold value;

means for calculating a slope between two of the ST segment data points that occur during the timer interval; and

means for determining whether the ST segment data points indicate ischemia based on the calculated slope.

14. The apparatus of claim 13, further comprising means for determining that the ST segment data points do not indicate supply ischemia if the calculated slope is less than a first slope value.

15. The apparatus of claim 13, further comprising means for determining that the ST segment data points indicate demand ischemia if the calculated slope is less than a first slope value.

16. The apparatus of claim 13, wherein the two of the ST segment data points are separated by a plurality of the ST segment data points.

17. The apparatus of claim 13, further comprising means for determining a maximum ST segment data point value during the timer interval, wherein the two of the ST segment data points include the maximum ST segment data point value.

18. The apparatus of claim 13, further comprising means for determining a maximum ST segment data point value during the timer interval, wherein the two of the ST segment data points occur prior to the maximum ST segment data point value.

19. The apparatus of claim 13, further comprising:

means for determining a maximum ST segment data point value during the timer interval;

means for determining an amount of time from initiation of the timer interval until the maximum ST segment data point value occurs; and

means for determining whether the ST segment data points indicate ischemia based on the amount of time.

20. The apparatus of claim 19, further comprising means for determining that the ST segment data points do not indicate supply ischemia if the amount of time is less than a first short value or greater than a first long value.

21. The apparatus of claim 19, further comprising means for determining that the ST segment data points do not indicate supply ischemia if an ST segment data point occurring at a termination of the timer interval is less than a predetermined percentage of the maximum ST segment data point value.

22. The apparatus of claim 13, wherein the means for determining an ST segment data point further comprises:

means for identifying a peak of an R wave;

means for adding a predetermined time interval to the identified peak; and

means for identifying a recorded value at a time identified by the predetermined time interval after the peak of the R wave as the ST segment data point.

23. The apparatus of claim 22, further comprising:

means for determining a PR isoelectric baseline value; and

means for subtracting the PR isoelectric baseline value from the recorded value to identify the ST segment data point.

24. The apparatus of claim 13, further comprising means for determining that the ST segment data points do not indicate supply ischemia if less than a predetermined percentage of the ST segment data points occurring during the timer interval exceed the threshold value.