Controlled high efficiency lesion formation using high intensity ultrasound
First Claim
1. An ultrasonic system for destroying undesired tissue at an internal site within a body of a patient, comprising:
- (a) a probe that is sized to be inserted within a body of a patient;
(b) an ultrasonic transducer mounted proximate a distal end of the probe, said ultrasonic transducer being adapted to couple to a power supply to selectively energize the ultrasonic transducer so that it produces a focused beam of high intensity ultrasonic energy configured to heat tissue between the transducer and a focal point based on a combination of at least two of an f-number, an intensity, a time, and a direction of the beam of high intensity ultrasonic energy and to treat the undesired tissue at the focal point, wherein said high intensity ultrasonic energy is configured to heat tissue between the transducer and focal point to a level sufficient to cause a lesion to form between the focal point and the ultrasonic transducer and to not cause a lesion to form substantially beyond the focal point; and
(c) an ultrasound transmissive interface that is coupled to the distal end of the probe, said ultrasound transmissive interface being disposed and adapted to transmit the high intensity ultrasonic energy produced by the ultrasonic transducer into a target, said high intensity ultrasonic energy increasing a temperature of the undesired tissue.
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0 Petitions
Accused Products
Abstract
An ultrasound system used for both imaging and delivery high intensity ultrasound energy therapy to treatment sites and a method for treating tumors and other undesired tissue within a patient'"'"'s body with an ultrasound device. The ultrasound device has an ultrasound transducer array disposed on a distal end of an elongate, relatively thin shaft. In one form of the invention, the transducer array is disposed within a liquid-filled elastomeric material that more effectively couples ultrasound energy into the tumor, that is directly contacted with the device. Using the device in a continuous wave mode, a necrotic zone of tissue having a desired size and shape (e.g., a necrotic volume selected to interrupt a blood supply to a tumor) can be created by controlling at least one of the f-number, duration, intensity, and direction of the ultrasound energy administered. This method speeds the therapy and avoids continuously pausing to enable intervening normal tissue to cool.
461 Citations
12 Claims
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1. An ultrasonic system for destroying undesired tissue at an internal site within a body of a patient, comprising:
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(a) a probe that is sized to be inserted within a body of a patient; (b) an ultrasonic transducer mounted proximate a distal end of the probe, said ultrasonic transducer being adapted to couple to a power supply to selectively energize the ultrasonic transducer so that it produces a focused beam of high intensity ultrasonic energy configured to heat tissue between the transducer and a focal point based on a combination of at least two of an f-number, an intensity, a time, and a direction of the beam of high intensity ultrasonic energy and to treat the undesired tissue at the focal point, wherein said high intensity ultrasonic energy is configured to heat tissue between the transducer and focal point to a level sufficient to cause a lesion to form between the focal point and the ultrasonic transducer and to not cause a lesion to form substantially beyond the focal point; and (c) an ultrasound transmissive interface that is coupled to the distal end of the probe, said ultrasound transmissive interface being disposed and adapted to transmit the high intensity ultrasonic energy produced by the ultrasonic transducer into a target, said high intensity ultrasonic energy increasing a temperature of the undesired tissue. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A method for administering an ultrasonic therapy to a target, comprising the steps of:
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(a) providing an ultrasonic transducer that emits a focused high energy ultrasonic energy when energized; (b) positioning the ultrasonic transducer to focus it at an imaged target; (c) directing the ultrasonic transducer toward a desired focal point within the target; (d) energizing the ultrasonic transducer so that it emits the focused high energy ultrasonic energy at the desired focal point, causing heating of a portion of the target disposed at the desired focal point; and (e) controlling a combination of at least two of an f-number, an intensity, a time, and a direction of the high intensity ultrasonic energy emitted into the target without moving the focal point to cause an initial lesion to grow toward the ultrasonic transducer and in at least one other dimension and not away from the ultrasonic transducer. - View Dependent Claims (9, 10, 11, 12)
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Specification