Systems, devices, and methods for improving accuracy of biosensors using fill time
First Claim
1. A method for determining a concentration of an analyte in a sample, the method comprising:
- detecting a presence of the sample in an electrochemical sensor, the electrochemical sensor comprising two electrodes;
determining a fill time of the sample with the two electrodes;
calculating a correction factor in view of at least the fill time;
reacting an analyte to cause a physical transformation of the analyte between the two electrodes; and
determining the concentration of the analyte in view of the correction factor with the same two electrodes; and
wherein determining the fill time of the sample comprises;
applying an electric potential between the two electrodes while the sample is introduced;
measuring a current as a function of time; and
determining a current drop time based on the current as a function of time, wherein the current drop time corresponds to the fill time of the sample.
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Accused Products
Abstract
Methods for determining a concentration of an analyte in a sample, and the devices and systems used in conjunction with the same, are provided herein. In one exemplary embodiment of a method for determining a concentration of an analyte in a sample, the method includes detecting a presence of a sample in an electrochemical sensor including two electrodes. A fill time of the sample is determined with the two electrodes and a correction factor is calculated in view of at least the fill time. The method also includes reacting an analyte that causes a physical transformation of the analyte between the two electrodes. A concentration of the analyte can then be determined in view of the correction factor with the same two electrodes. Systems and devices that take advantage of the fill time to make analyte concentration determinations are also provided.
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Citations
52 Claims
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1. A method for determining a concentration of an analyte in a sample, the method comprising:
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detecting a presence of the sample in an electrochemical sensor, the electrochemical sensor comprising two electrodes; determining a fill time of the sample with the two electrodes; calculating a correction factor in view of at least the fill time; reacting an analyte to cause a physical transformation of the analyte between the two electrodes; and determining the concentration of the analyte in view of the correction factor with the same two electrodes; and wherein determining the fill time of the sample comprises; applying an electric potential between the two electrodes while the sample is introduced; measuring a current as a function of time; and determining a current drop time based on the current as a function of time, wherein the current drop time corresponds to the fill time of the sample. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A method for measuring a corrected analyte cancentration, the method comprising:
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detecting a presence of the sample in an electrochemical sensor, the electrochemical sensor comprising two electrodes; determining a fill time of the sample with the two electrodes; reacting an analyte to cause a physical transformation of the analyte; determining a first analyte concentration in the sample with the same tow electrodes; and calculating a corrected analyte concentration based on the first analyte concentration and the fill time wherein determining the fill time of the sample comprises; applying an electric potential between the two electrodes while the sample is introduced; measuring a current as a function of time; and determining a current drop time based on the current as a function of time, wherein the current drop time corresponds to the fill time of the sample. - View Dependent Claims (21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40)
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41. An electrochemical system, comprising:
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(a) an electrochemical sensor including electrical contacts configured to mate with a test meter, the electrochemical sensor comprising; (i) a first electrode and a second electrode in a spaced apart relationship, and (ii) a reagent; and (b) the test meter including a processor configured to receive current data from the electrochemical sensor upon application of voltages to the electrochemical sensor, and further configured to determine a corrected analyte concentration based on a calculated analyte concentration and a measured fill time with the same two electrodes and wherein the fill time corresponds to a determined current drop time. - View Dependent Claims (42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52)
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Specification