Method for the treatment of lung tumors
First Claim
1. A method of inhibiting cancer growth in the lungs of a mammal comprising inhalation administration of aerosol particles of a pharmaceutical formulation of an anti-cancer drug comprising paclitaxel, α
- -tocopheryl succinate, sorbitan trioleate, ethanol, and carbon dioxide, wherein the pressure of the formulation is maintained between 900 and 5000 psi prior to spraying the formulation through a valve into a region of ambient atmospheric pressure for inhalation administration.
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Abstract
The present invention provides a method of inhibiting cancer growth in the lungs of a mammal through the inhalation administration of aerosol particles of an anti-cancer drug formulation. Further, the present invention provides a formulation for aerosol delivery that comprises a combination of paclitaxel, α-tocopheryl succinate; sorbitan trioleate, ethanol, and carbon dioxide. Prior studies have indicated that aerosol administration of cancer drugs holds great potential as a treatment modality, both for lung cancer and for lung metastases of other cancers. Practice of the invention has been demonstrated using a mouse model of lung cancer, in which intrapulmonary deposition of paclitaxel by aerosol inhalation reduced lung tumor size and increased body weight in tumor-bearing mice.
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Citations
14 Claims
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1. A method of inhibiting cancer growth in the lungs of a mammal comprising inhalation administration of aerosol particles of a pharmaceutical formulation of an anti-cancer drug comprising paclitaxel, α
- -tocopheryl succinate, sorbitan trioleate, ethanol, and carbon dioxide, wherein the pressure of the formulation is maintained between 900 and 5000 psi prior to spraying the formulation through a valve into a region of ambient atmospheric pressure for inhalation administration.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A method of treating primary or metastatic lung tumors in a mammal, comprising spraying a pressurized formulation comprising a combination of paclitaxel, α
- -tocopheryl succinate, sorbitan trioleate, ethanol, and supercritical carbon dioxide from a high pressure vessel in which the formulation pressure is maintained between 900 and 5000 psi into an atmospheric pressure region to form an airborne aerosol mixture that is subsequently inhaled by said mammal.
- View Dependent Claims (11, 12, 13, 14)
Specification