Anti-IL-6 antibodies
First Claim
Patent Images
1. A liquid pharmaceutical formulation of an isolated IL-6 antibody, comprising at least one light chain variable region and one heavy chain variable region, said light chain variable region comprising:
- a complementarity determining region light chain 1 (CDRL1) amino acid sequence of SEQ ID NO;
132 comprising the sequence S-X1-X2-X3-X4-V-X5-Y-M-Y, wherein X1 is A or G, X2 is S or R, X3 is H, I, S, or Y, X4 is S or Y, and X5 is S or F;
a CDRL2 amino acid sequence of SEQ ID NO;
133 comprising the sequence D-X6-S-X7-L-X8-S, wherein X6 is F, L, M, or T, X7 is N or E, and X8 is A or T; and
a CDRL3 amino acid sequence of SEQ ID NO;
134 comprising the sequence X9-X10-W-S-G-Y-P-Y-T, wherein X9 is M, C, or S, and X10 is Q or C;
said heavy chain variable region comprising;
a complementarity determining region heavy chain 1 (CDRH1) amino acid sequence of SEQ ID NO;
135 comprising the sequence G-F-X11-X12-S-X13-F-A-X14-S, wherein X11 is T or Q, X12 is F, S, or T, X13 is S or P, and X14 is L or M;
a CDRH2 amino acid sequence of SEQ ID NO;
136 comprising the sequence K-X15-S-X16-G-G-S-X17-X18-Y-X19-X20-D-T-X21-X22-X23, wherein X15 is A or I, X16 is S or P, X17 is Y or W, X18 is T, E, or Y, X19 is Y or F, X20 is P, S, D, or F, X21 is V or D, X22 is T or A, and X23 is G or P; and
a CDRH3 amino acid sequence of SEQ ID NO;
137 comprising the sequence Q-L-W-G-X24-Y-A-L-D-X25, wherein X24 is S, Y, T, or N, and X25 is Y, T, F, or I.
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Abstract
An anti-IL-6 antibody, including isolated nucleic acids that encode at least one anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
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Citations
11 Claims
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1. A liquid pharmaceutical formulation of an isolated IL-6 antibody, comprising at least one light chain variable region and one heavy chain variable region, said light chain variable region comprising:
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a complementarity determining region light chain 1 (CDRL1) amino acid sequence of SEQ ID NO;
132 comprising the sequence S-X1-X2-X3-X4-V-X5-Y-M-Y, wherein X1 is A or G, X2 is S or R, X3 is H, I, S, or Y, X4 is S or Y, and X5 is S or F;a CDRL2 amino acid sequence of SEQ ID NO;
133 comprising the sequence D-X6-S-X7-L-X8-S, wherein X6 is F, L, M, or T, X7 is N or E, and X8 is A or T; anda CDRL3 amino acid sequence of SEQ ID NO;
134 comprising the sequence X9-X10-W-S-G-Y-P-Y-T, wherein X9 is M, C, or S, and X10 is Q or C;
said heavy chain variable region comprising;a complementarity determining region heavy chain 1 (CDRH1) amino acid sequence of SEQ ID NO;
135 comprising the sequence G-F-X11-X12-S-X13-F-A-X14-S, wherein X11 is T or Q, X12 is F, S, or T, X13 is S or P, and X14 is L or M;a CDRH2 amino acid sequence of SEQ ID NO;
136 comprising the sequence K-X15-S-X16-G-G-S-X17-X18-Y-X19-X20-D-T-X21-X22-X23, wherein X15 is A or I, X16 is S or P, X17 is Y or W, X18 is T, E, or Y, X19 is Y or F, X20 is P, S, D, or F, X21 is V or D, X22 is T or A, and X23 is G or P; anda CDRH3 amino acid sequence of SEQ ID NO;
137 comprising the sequence Q-L-W-G-X24-Y-A-L-D-X25, wherein X24 is S, Y, T, or N, and X25 is Y, T, F, or I. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A liquid pharmaceutical formulation, comprising an isolated IL-6 antibody having a complementarity determining region light chain 1 (CDRL1) amino acid sequence of SEQ ID NO:
- 3, a CDRL2 amino acid sequence of SEQ ID NO;
21, a CDRL3 amino acid sequence of SEQ ID NO;
29, a complementarity determining region heavy chain 1 (CDRH1) amino acid sequence of SEQ ID NO;
39, a CDRH2 amino acid sequence of SEQ ID NO;
59, and a CDRH3 amino acid sequence of SEQ ID NO;
89, acetate buffer, sorbitol, and polysorbate 20, wherein the pH is about 5.0.
- 3, a CDRL2 amino acid sequence of SEQ ID NO;
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11. A liquid pharmaceutical formulation, comprising an isolated IL-6 antibody having a light chain variable region amino acid sequence of SEQ ID NO:
- 97 and a heavy chain variable region amino acid sequence of SEQ ID NO;
99, acetate buffer, sorbitol, and polysorbate 20, wherein the pH is about 5.0.
- 97 and a heavy chain variable region amino acid sequence of SEQ ID NO;
Specification