Anti-ICAM-1 single domain antibody and uses thereof
First Claim
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1. An isolated or purified antibody or fragment thereof that specifically binds to intercellular adhesion molecule 1 (ICAM-1), comprisingthe sequence of complementarity determining region (CDR) 1 selected from sequences LYVMG (SEQ ID NO:
- 1), AFRMG (SEQ ID NO;
2), and INDMG (SEQ ID NO;
3);
the sequence of CDR2 selected from sequences DITSSGSIYYVDSLKG (SEQ ID NO;
4), VITAGGTTSYIDSVKG (SEQ ID NO;
5), and RITRDGSAAYEDSVKG (SEQ ID NO;
6); and
the sequence of CDR3 selected from sequences HVRQDSGSEYLTY (SEQ ID NO;
7), IDYDS (SEQ ID NO;
8), and EIITTQTLGRMLGEY (SEQ ID NO;
9).
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Accused Products
Abstract
Anti-ICAM-1 VHH single-domain antibodies (sdAbs) are generated by immunizing a llama with recombinant ICAM-1. These antibodies are linked to an imaging moiety for in vivo or ex vivo imaging of ICAM-1-related pathological conditions including atherosclerotic plaques. The antibodies may also be linked to a therapeutic agent to specifically target and treat ICAM-1-related pathological conditions.
5 Citations
19 Claims
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1. An isolated or purified antibody or fragment thereof that specifically binds to intercellular adhesion molecule 1 (ICAM-1), comprising
the sequence of complementarity determining region (CDR) 1 selected from sequences LYVMG (SEQ ID NO: - 1), AFRMG (SEQ ID NO;
2), and INDMG (SEQ ID NO;
3);the sequence of CDR2 selected from sequences DITSSGSIYYVDSLKG (SEQ ID NO;
4), VITAGGTTSYIDSVKG (SEQ ID NO;
5), and RITRDGSAAYEDSVKG (SEQ ID NO;
6); andthe sequence of CDR3 selected from sequences HVRQDSGSEYLTY (SEQ ID NO;
7), IDYDS (SEQ ID NO;
8), and EIITTQTLGRMLGEY (SEQ ID NO;
9). - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
- 1), AFRMG (SEQ ID NO;
Specification