Biomatrix structural containment and fixation systems and methods of use thereof
First Claim
1. A biomatrix containment and fixation system comprisinga containment and fixation sleeve including one or more sheet(s) of biomatrix material, the one or more of the sheet(s) having one or more biocompatible proteins combined with one or more biocompatible solvents to form a cohesive body having a solvent content of about 10% to 80% by weight prior to compression, the cohesive body is compressed at a pressure of about 100 psi to about 100,000 psi to form the sheet(s) of biomatrix material having a solvent content of about 5% to 60% by weight, said sleeve having two or more ends adhered together with one or more fastening device(s) to form an enclosure;
- anda plurality of protein particles positioned within the enclosure of the sleeve, said protein particles including one or more biocompatible proteins combined with one or more biocompatible solvents and one or more pharmacologically active agents.
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Accused Products
Abstract
The containment and fixation system of the present invention generally includes a biomatrix sleeve, biomatrix particles or combinations thereof made of a biomatrix material. The biomatrix material is comprised of one or more biocompatible proteins and one or more biocompatible solvents. The biomatrix material utilized in the sleeve and/or particles may also include one or more pharmacologically active agents like therapeutic biochemicals such as a bone mending biochemical (e.g. hydroxyapatite) or an angiogenic growth factor (e.g. BMP).
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Citations
19 Claims
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1. A biomatrix containment and fixation system comprising
a containment and fixation sleeve including one or more sheet(s) of biomatrix material, the one or more of the sheet(s) having one or more biocompatible proteins combined with one or more biocompatible solvents to form a cohesive body having a solvent content of about 10% to 80% by weight prior to compression, the cohesive body is compressed at a pressure of about 100 psi to about 100,000 psi to form the sheet(s) of biomatrix material having a solvent content of about 5% to 60% by weight, said sleeve having two or more ends adhered together with one or more fastening device(s) to form an enclosure; - and
a plurality of protein particles positioned within the enclosure of the sleeve, said protein particles including one or more biocompatible proteins combined with one or more biocompatible solvents and one or more pharmacologically active agents. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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Specification