Compositions and methods for stabilized polysaccharide formulations
First Claim
1. A composition for treating a joint condition, comprising:
- a formulation comprising high molecular weight hyaluronic acid (HA); and
at least one stabilizer, wherein the stabilizer increases stability of the formulation, wherein the at least one stabilizer comprises trehalose, and wherein the trehalose is present in a range of about 0.1% to 50% by weight of the composition.
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Accused Products
Abstract
Compositions and methods are provided for treating joint conditions, such as osteoarthritis and/or the pain associated therewith. The compositions and methods utilize a first component, namely hyaluronic acid (“HA”), in combination with at least one stabilizer. The composition can include a stabilizer that increases the stability and shelf-life of the HA. In another embodiment, the compositions and methods can also include an additional component, such as one or more glycosaminoglycans (“GAG”) or GAG precursors. Examples of GAGs or GAG precursors can include chondroitin sulfate (“CS”), dermatan sulfate, heparin, heparan sulfate, keratan sulfate, and glucosamine (“GlcN”).
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Citations
19 Claims
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1. A composition for treating a joint condition, comprising:
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a formulation comprising high molecular weight hyaluronic acid (HA); and at least one stabilizer, wherein the stabilizer increases stability of the formulation, wherein the at least one stabilizer comprises trehalose, and wherein the trehalose is present in a range of about 0.1% to 50% by weight of the composition. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A kit, comprising:
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a composition of high molecular weight hyaluronic acid (HA) and at least one stabilizer, wherein the at least one stabilizer comprises trehalose, and wherein the trehalose is present in a rang of about 0.1% to 50% by weight of the composition; and a syringe comprising the composition of HA and stabilizer in a single chamber. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16)
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17. A method for treating joints, comprising:
administering a formulation comprising high molecular weight hyaluronic acid and at least one stabilizer to a subject in need thereof, wherein the at least one stabilizer comprises trehalose, and wherein the trehalose is present in a range of about 0.1% to 50% by weight of the composition. - View Dependent Claims (18, 19)
Specification