Medicament delivery device for administration of opioid antagonists including formulations for naloxone
First Claim
Patent Images
1. An apparatus, comprising:
- a housing;
a medicament container disposed within the housing, the medicament container containing a naloxone composition;
an elastomeric member movably disposed within the medicament container, the elastomeric member formulated to be compatible with the naloxone composition, at least a portion of the elastomeric member being coated with a silicone-based material; and
an energy storage member disposed within the housing, the energy storage member configured to produce a force that is exerted on the elastomeric member to deliver the naloxone composition,wherein the naloxone composition includes naloxone or salts thereof, a tonicity-adjusting agent, and a pH adjusting agent, whereby the osmolality of the naloxone composition ranges from about 250-350 mOsm and the pH ranges from about 3-5.
3 Assignments
0 Petitions
Accused Products
Abstract
Medicament delivery devices for administration of opioid antagonists are described herein. In some embodiments, an apparatus includes a housing, a medicament container disposed within the housing and an energy storage member disposed within the housing. The medicament container is filled with a naloxone composition that includes naloxone or salts thereof, a tonicity-adjusting agent, and a pH adjusting agent, whereby the osmolality of the naloxone composition ranges from about 250-350 mOsm and the pH ranges from about 3-5. The energy storage member is configured to produce a force to deliver the naloxone composition.
430 Citations
32 Claims
-
1. An apparatus, comprising:
-
a housing; a medicament container disposed within the housing, the medicament container containing a naloxone composition; an elastomeric member movably disposed within the medicament container, the elastomeric member formulated to be compatible with the naloxone composition, at least a portion of the elastomeric member being coated with a silicone-based material; and an energy storage member disposed within the housing, the energy storage member configured to produce a force that is exerted on the elastomeric member to deliver the naloxone composition, wherein the naloxone composition includes naloxone or salts thereof, a tonicity-adjusting agent, and a pH adjusting agent, whereby the osmolality of the naloxone composition ranges from about 250-350 mOsm and the pH ranges from about 3-5. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
-
-
24. An apparatus, comprising:
-
a housing; a medicament container disposed within the housing, the medicament container containing a naloxone composition; an elastomeric member disposed within the medicament container, at least a portion of the elastomeric member coated with a silicone-based material; and an energy storage member disposed within the housing, the energy storage member configured to produce a force that is exerted on the elastomeric member to deliver the naloxone composition, wherein the naloxone composition includes naloxone or salts thereof, a tonicity-adjusting agent, and a pH adjusting agent, whereby at least one of the osmolality of the naloxone composition ranges from about 250-350 mOsm or the pH of the naloxone composition ranges from about 3-5. - View Dependent Claims (25, 26, 27, 28, 29, 30, 31, 32)
-
Specification