Emergency preservation and resuscitation methods
First Claim
1. A method of inducing preservation in a patient suffering from cardiopulmonary arrest, comprising cooling the patient within about 8 minutes of cardiopulmonary arrest or cessation of cardiopulmonary resuscitation by flushing the patient'"'"'s vasculature, including at least the patient'"'"'s heart and brain, with an oxygenated, aqueous cold-flush solution comprising an energy source, wherein the cold-flush solution is introduced into the patient at from about 1°
- C. to about 4°
C. and the patient is cooled to a tympanic temperature of less than 10°
C. in a time period of less than 27 minutes.
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Accused Products
Abstract
Provided are methods for inducing preservation in a patient and resuscitating that patient. At least three hours of preservation, with successful resuscitation, are realized using the methods described herein. The methods involve flushing a patient with an oxygenated, cold-flush solution, such as normal saline, having an energy source. The patient may be cooled to deep or profound hypothermia to induce preservation. The patient may be resuscitated by warming to from about 33° C. to about 36° C., and then may be slowly warmed over a 24 to 72 hour period to normothermia. Kits for inducing preservation also are provided.
64 Citations
48 Claims
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1. A method of inducing preservation in a patient suffering from cardiopulmonary arrest, comprising cooling the patient within about 8 minutes of cardiopulmonary arrest or cessation of cardiopulmonary resuscitation by flushing the patient'"'"'s vasculature, including at least the patient'"'"'s heart and brain, with an oxygenated, aqueous cold-flush solution comprising an energy source, wherein the cold-flush solution is introduced into the patient at from about 1°
- C. to about 4°
C. and the patient is cooled to a tympanic temperature of less than 10°
C. in a time period of less than 27 minutes. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32)
- C. to about 4°
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33. A method of preserving organs of a cadaver, comprising, cooling the cadaver by flushing the cadaver'"'"'s blood vessels, including at least the cadaver'"'"'s heart and brain, with an oxygenated cold-flush solution comprising an energy source, wherein the cooling solution is about 1°
- C. to about 4°
C. and the cadaver is cooled to a tympanic temperature of less than 10°
C. in a time period of less than 27 minutes. - View Dependent Claims (34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48)
- C. to about 4°
Specification