Stent with drug coating with variable release rate
First Claim
Patent Images
1. A strut network for a radially expandable stent, comprising:
- generally linear segments interrupted by a curved or bent segment; and
a surface coating containing a drug disposed on the generally linear segments and on the curved or bent segment, wherein a release rate of the drug from the surface coating is greater in the curved or bent segment as compared to the generally linear segments,wherein a concentration of the drug in the surface coating is substantially the same over the generally linear segments and the curved or bent segment, the concentration is the amount of drug per amount of surface coating, andwherein the strut network further comprises a proximal end, a distal end, and an intermediate portion connecting the proximal end to the distal end, and the curved or bent segment and the generally linear segments are disposed within the intermediate portion.
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Abstract
A stent is provided with a coating having a variable drug release rate. The release rate can be greater over a curved or bent segment of a strut network as compared to generally linear segments of the strut network. The coating can have a barrier region that is thicker over the generally linear segments. The coating can have a drug mixed with polymers. The curved or bent segment can have a greater amount of a polymer having relatively high drug permeability as compared to the generally linear segments.
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Citations
16 Claims
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1. A strut network for a radially expandable stent, comprising:
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generally linear segments interrupted by a curved or bent segment; and a surface coating containing a drug disposed on the generally linear segments and on the curved or bent segment, wherein a release rate of the drug from the surface coating is greater in the curved or bent segment as compared to the generally linear segments, wherein a concentration of the drug in the surface coating is substantially the same over the generally linear segments and the curved or bent segment, the concentration is the amount of drug per amount of surface coating, and wherein the strut network further comprises a proximal end, a distal end, and an intermediate portion connecting the proximal end to the distal end, and the curved or bent segment and the generally linear segments are disposed within the intermediate portion. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A strut network for a radially expandable stent, comprising:
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generally linear segments interrupted by a curved or bent segment; and a surface coating containing a drug disposed on the generally linear segments and on the curved or bent segment, wherein a release rate of the drug from the surface coating is greater in the curved or bent segment as compared to the generally linear segments, wherein a thickness of the surface coating is greater at the generally linear segments than at the curved or bent segment, a concentration of the drug in the surface coating is substantially the same over the generally linear segments and the curved or bent segment, the concentration is the amount of drug per amount of surface coating, and wherein the strut network further comprises a proximal end, a distal end, and an intermediate portion connecting the proximal end to the distal end, and the curved or bent segment and the generally linear segments are disposed within the intermediate portion. - View Dependent Claims (10, 11)
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12. A strut network for a radially expandable stent, comprising:
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generally linear segments interrupted by a curved or bent segment; and a surface coating containing a drug disposed on the generally linear segments and on the curved or bent segment, wherein a release rate of the drug from the surface coating is greater in the curved or bent segment as compared to the generally linear segments, wherein a concentration of the drug in the surface coating is substantially the same over the generally linear segments and the curved or bent segment, the concentration is the amount of drug per amount of surface coating, wherein the drug is mixed or dispersed in a mixture of a first polymer and a second polymer, the first polymer having a greater drug permeability than the second polymer, and wherein the mixture, for the curved or bent segment, has a greater proportion of the first polymer than the second polymer.
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13. A strut network for a radially expandable stent, comprising:
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generally linear segments interrupted by a curved or bent segment; and a surface coating containing a drug disposed on the generally linear segments and on the curved or bent segment, wherein a release rate of the drug from the surface coating is greater in the curved or bent segment as compared to the generally linear segments, wherein a concentration of the drug in the surface coating is substantially the same over the generally linear segments and the curved or bent segment, the concentration is the amount of drug per amount of surface coating, wherein the drug is mixed or dispersed in a mixture of a first polymer and a second polymer, the first polymer having a greater drug permeability than the second polymer, and wherein the mixture, for the generally linear segments, has a lesser proportion of the first polymer than the second polymer.
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14. A strut network for a radially expandable stent, comprising:
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generally linear segments interrupted by a curved or bent segment; and a surface coating containing a drug disposed on the generally linear segments and on the curved or bent segment, wherein a release rate of the drug from the surface coating is greater in the curved or bent segment as compared to the generally linear segments, wherein a concentration of the drug in the surface coating is substantially the same over the generally linear segments and the curved or bent segment, the concentration is the amount of drug per amount of surface coating, and wherein the release rate of the drug from the surface coating is greatest at the vertex of the curved or bent segment as compared to other portions of the curved or bent segment. - View Dependent Claims (15, 16)
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Specification