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Cancer imaging and treatment

  • US 8,628,750 B2
  • Filed: 02/27/2007
  • Issued: 01/14/2014
  • Est. Priority Date: 02/27/2006
  • Status: Expired due to Fees
First Claim
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1. A compound or conjugate, or a pharmaceutically acceptable salt or ester thereof, comprising a ligand for the chemokine receptor CXCR4 and a detectable label, the ligand having a binding affinity for the CXCR4 receptor, measured as IC50 in the presence of 125I-CPCR4, of 250 nM or lower, wherein the ligand comprises a cyclic oligopeptide moiety, wherein the cyclic oligopeptide moiety is:

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