Use of quinazoline derivatives for the treatment of viral diseases
First Claim
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1. A method for the treatment of viral infection and exacerbation in respiratory diseases comprising administering to a patient in need thereof a therapeutically effective amount of a compound of formula (IV)
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Abstract
The present invention relates to the use of quinazoline derivatives, which show EGFR inhibitory activity, for the prevention and/or treatment of virus-induced diseases, preferably virus induced respiratory diseases and exacerbation in chronic airway diseases such as COPD or asthma.
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6 Claims
- 1. A method for the treatment of viral infection and exacerbation in respiratory diseases comprising administering to a patient in need thereof a therapeutically effective amount of a compound of formula (IV)
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2. A method for the treatment of viral infection and exacerbation in respiratory diseases comprising administering to a patient in need thereof a therapeutically effective amount of a compound selected from the group consisting of
(1.86) anti-9-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-1,4-diaza-spiro[5.5]undecan-5-one, (1.87) syn-9-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-1,4-diaza-spiro[5.5]undecan-5-one, (1.88) anti-9-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-1-methyl-1,4-diaza-spiro[5.5]undecan-5-one, (1.89) anti-9-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-1,4-dimethyl-1,4-diaza-spiro[5.5]undecan-5-one, (1.90) anti-8-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-1,3-diaza-spiro[4.5]decan-2,4-dione, (1.91) syn-8-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-1,3-diaza-spiro[4.5]decan-2,4-dione, and the tautomers, racemates, enantiomers, diastereomers and pharmacologically acceptable acid addition salts thereof.
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