Dialysis systems including non-invasive multi-function sensor systems

• US 8,631,683 B2
• Filed: 12/28/2009
• Issued: 01/21/2014
• Est. Priority Date: 02/06/2007
• Status: Active Grant

• Current Assignee: Fresenius Medical Care Holdings Incorporated (Fresenius Medical Care AG)
• Original Assignee: Fresenius Medical Care Holdings Incorporated (Fresenius Medical Care AG)
• Inventors: Dam, Naim, Crnkovich, Martin Joseph, Levin, Roland
• Primary Examiner(s): Macchiarolo, Peter
• Assistant Examiner(s): MILLER, ROSE MARY
• Application Number:
  US12/647,820
• Publication Number:
  US 20110009800A1
• Time in Patent Office: 1,485 Days
• Field of Search: 73/190.3, 73/617.5, 735/97, 735/98, 600/6.08, 604/6.08, 250/343
• US Class Current: 73/19.03
• CPC Class Codes: A61M 1/3609 Physical characteristics of the blood, e.g. haematocrit, urea
• CPC Class Codes: A61M 1/3623 Means for actively controlling temperature of blood
• CPC Class Codes: A61M 1/3626 Gas bubble detectors
• CPC Class Codes: A61M 1/3639 Blood pressure control, pressure transducers specially adapted therefor
• CPC Class Codes: A61M 1/3658 Indicating the amount of purified blood recirculating in the fistula or shunt
• CPC Class Codes: A61M 2205/331 used as turbidity change detectors, e.g. for priming-blood or plasma-hemoglubine-interface detection
• CPC Class Codes: A61M 2205/3375 Acoustical, e.g. ultrasonic, measuring means
• CPC Class Codes: G01N 21/25 Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
• CPC Class Codes: G01N 2291/022 Liquids
• CPC Class Codes: G01N 2291/02433 Gases in liquids, e.g. bubbles, foams
• CPC Class Codes: G01N 2291/02466 Biological material, e.g. blood
• CPC Class Codes: G01N 29/02 Analysing fluids using acoustic emission techniques G01N29/14 ; constructional or flow details for analysing fluids G01N29/222; optoacoustic fluid cells G01N29/2425
• CPC Class Codes: G01N 29/2437 Piezoelectric probes

Abstract

A dialysis system that includes a dialysis machine, a tube connected to the dialysis machine, and a sensor system. The sensor system includes a head having a slot configured to receive the tube and a plurality of sensors secured to the head adjacent the slot. At least one of the plurality of sensors includes a light emitting element configured to transmit light through the tube when the tube is disposed in the slot and a light receiving element configured to receive the light emitted by the light emitting element after the light passes trough the tube.

Claims

1. A dialysis system, comprising:

a dialysis machine;

a tube connected to the dialysis machine;

a sensor system, comprising

a head having a slot configured to receive the tube; and

a plurality of sensors secured to the head adjacent the slot,

wherein the plurality of sensors comprise;

a light emitting element configured to transmit light through the tube when the tube is disposed in the slot;

a light receiving element configured to receive the light emitted by the light emitting element after the light passes through the tube, and

an infrared temperature sensor element configured to project infrared energy into the tube when the tube is disposed in the slot,

wherein the sensor system further comprises a temperature sensing circuit responsive to infrared energy sensed by the infrared temperature sensor element to determine a temperature of fluid in the tube;

a resistive heater; and

a microprocessor in communication with the plurality of sensors, wherein the microprocessor is configured to activate the resistive heater to adjust a temperature of dialysate flowing through a dialyzer of the dialysis system based on a temperature of fluid in the tube determined by the temperature sensing circuit,

wherein fluid in the tube is blood, the tube is a venous line, and the dialysis system further comprises an arterial line and a second temperature sensor configured to measure a temperature of blood flowing through the arterial line, and

wherein the microprocessor is configured to control the resistive heater in a manner to heat a bolus of dialysate to a temperature greater than a temperature of blood flowing through the dialysis system in order to heat blood flowing through the dialyzer, and to compare a temperature of blood in the arterial line as detected by the second temperature sensor to a temperature of blood in the venous line as detected by the infrared temperature sensor to determine whether recirculation is present.

2. The dialysis system of claim 1, wherein the tube comprises a plurality of tubular segments connected together.

3. The dialysis system of claim 1, wherein the tube is connected to a patient in a manner such that fluid can be drawn from the patient via the tube.

4. The dialysis system of claim 1, wherein the tube is connected to a patient in a manner such that fluid can be delivered to the patient via the tube.

5. The dialysis system of claim 1, wherein the sensor system further comprises a liquid type detection circuit responsive to the light received by the light receiving element to determine the color of fluid in the tube.

6. The dialysis system of claim 5, wherein the liquid type detection circuit also operates to determine whether the tube is present in the slot.

7. The dialysis system of claim 5, wherein the liquid type detection circuit also operates to determine whether liquid is in the tube.

8. The dialysis system of claim 5, wherein the sensor system further comprises a multiplexer controlled by timing signals to separately actuate the liquid type circuit and a circuit associated with at least one of the other sensors.

9. The dialysis system of claim 1, wherein at least one of the plurality of sensors comprises:

a first piezoelectric element mounted on a first wall of the head adjacent the slot; and

a second piezoelectric element mounted on a second wall of the head adjacent the slot, the second wall being opposite the first wall.

10. The dialysis system of claim 9, wherein, when the tube is disposed in the slot of the head, the first piezoelectric element and the second piezoelectric element are positioned outside of the tube and are configured to detect an air bubble in fluid in the tube.

11. The dialysis system of claim 10, wherein the sensor system further comprises an air bubble detection circuit to supply ultrasonic energy to one of the piezoelectric sensor elements, to receive the ultrasonic energy transmitted through the tube by the other of the piezoelectric sensor elements, and to determine from the received energy whether an air bubble is present in fluid in the tube.

12. The dialysis system of claim 1, wherein at least one of the plurality of sensors is a force sensor.

13. The dialysis system of claim 12, wherein the sensor system further comprises a force detection circuit to determine a force applied to the force sensor by the tube.

14. The dialysis system of claim 13, wherein the force detection circuit is configured to determine whether the tube is present in the slot.

15. The dialysis system of claim 13, wherein the force detection circuit is configured to determine an internal pressure of the tube.

16. The dialysis system of claim 12, wherein the force sensor contacts an outer surface of the tube when the tube is disposed in the slot.

17. The dialysis system of claim 1, wherein walls of the head adjacent the slot define recesses in which the plurality of sensors are disposed.

18. The dialysis system of claim 17, wherein the walls of the head further define passages extending from the recesses to outer surfaces of the walls, and wires connected to the sensors extend through the passages to a location external the head.

19. The dialysis system of claim 1, wherein the slot has a width that is less than a width of the tube when the tube is undeformed.

20. The dialysis system of claim 1, wherein the head of the sensor system is made of a transparent plastic material.

21. The dialysis system of claim 1, wherein the dialysis machine is a hemodialysis machine.

22. The dialysis system of claim 1, wherein the microprocessor is configured to activate an alarm based on signals from the sensors.

23. The dialysis system of claim 1, further comprising a display device in communication with the microprocessor, wherein the microprocessor is configured to drive the display device to display measurement results based on signals received from the sensors.

24. The dialysis system of claim 1, further comprising a display device, wherein the microprocessor is configured to drive the display device to display warnings based on signals received from the sensors.

25. The dialysis system of claim 1, further comprising a blood pump in communication with the microprocessor, wherein the microprocessor is configured to control operation of the blood pump based on signals received from the sensors.

26. The dialysis system of claim 1, wherein the microprocessor is configured to adjust the temperature of the dialysate flowing through the dialyzer to match the temperature of the fluid in the tube.

27. The dialysis system of claim 1, wherein the fluid in the tube is blood and the tube is connected to the dialyzer such that the blood flows through the dialyzer along with the dialysate.

28. The dialysis system of claim 1, wherein the microprocessor is configured to determine that recirculation is present if the second temperature detects a bolus of blood having an elevated temperature, as compared to other blood flowing through the venous line.

29. The dialysis system of claim 1, wherein the microprocessor is configured to lower a blood flow rate through the dialysis system if recirculation is determined to be present.

30. The dialysis system of claim 1, wherein the microprocessor is configured to activate an alarm of the dialysis system if recirculation is determined to be present.