Devices, systems, and methods for mapping organ profiles

• US 8,632,469 B2
• Filed: 01/23/2008
• Issued: 01/21/2014
• Est. Priority Date: 02/21/2003
• Status: Active Grant

• Current Assignee: 3DT Holdings LLC
• Original Assignee: 3DT Holdings LLC
• Inventors: Kassab, Ghassan S.
• Primary Examiner(s): Matthews, Christine
• Assistant Examiner(s): Reddy, Sunita
• Application Number:
  US12/522,432
• Publication Number:
  US 20100010355A1
• Time in Patent Office: 2,190 Days
• Field of Search: 600/481, 600482-507, 600/466, 600/468, 600/381
• US Class Current: 600/481
• CPC Class Codes: A61B 2560/0223 of calibration, e.g. protocols for calibrating sensors
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00
• CPC Class Codes: A61B 5/053 Measuring electrical impedance or conductance of a portion of the body
• CPC Class Codes: A61B 5/0538 invasively, e.g. using a catheter

Abstract

Devices, systems, and methods for the localization of body lumen junctions and other intraluminal structure are disclosed. Various embodiments permit clinicians to identify and locate lesions and/or anatomical structures within a lumen and accurately place leads and/or devices within a lumen, through determining the intralumen conductance and/or cross-sectional area at a plurality of locations within the body lumen.

Claims

1. A system comprising:

a device having a proximal end and a distal end, the distal end of the device configured for placement into a body lumen, the device comprising a first electrode located between the proximal and distal ends of the device; and

a processor operably connected to the first electrode of the device, the processor operable to collect conductance data from the device to determine a profile of the body lumen based upon the conductance data, the conductance data collected at a plurality of locations within the body lumen and determined at each of the plurality of locations when the first electrode is immersed in a fluid within the body lumen;

wherein the processor further comprises a computational program configured to detect a bifurcation in the body lumen based upon the conductance data obtained at the plurality of locations and changes in cross-sectional area identified using the conductance data, the conductance data including data obtained at the bifurcation using the device, and distinguishing the bifurcation from a lesion.

2. The system of claim 1, wherein the processor is further capable of calculating a cross-sectional area of the body lumen at each of the plurality of locations within the body lumen using the conductance data.

3. The system of claim 1, wherein the computational program is further configured to adjust the conductance data to eliminate a conductance spike due to the detection of a bifurcation.

4. The system of claim 1, wherein the device is selected from the group consisting of an impedance catheter and an impedance wire.

5. The system of claim 1, wherein, the body lumen comprises an aortic lumen.

6. The system of claim 5, wherein the lesion comprises an aneurysm.

7. The system of claim 1, wherein the body lumen comprises a lumen of a coronary artery.

8. The system of claim 1, wherein the device further comprises a third electrode and a fourth electrode, wherein the first and third electrodes comprise excitation electrodes and the second and fourth electrodes comprise detection electrodes;

and the third and fourth electrodes are operably connected to the processor.

9. The system of claim 8, wherein the fluid comprises blood.

10. The system of claim 1, wherein the computational program comprises a smoothing algorithm.

11. The system of claim 10, wherein the computational program further comprises a threshold limit.

12. The system of claim 1, wherein the computational program comprises a gradient.

13. The system of claim 1, wherein the computational program comprises an interpolation.

14. The system of claim 1, wherein the computational program comprises a threshold limit.

15. A system comprising:

a catheter having a proximal end and a distal end, the distal end of the catheter configured for placement into a body lumen, the catheter comprising a first electrode and a second electrode located between the proximal and distal ends of the catheter, the catheter further comprising a passageway configured for passing fluid through the catheter to a location of the first and second electrodes, such that fluid passing through the passageway comes in contact with the first and second electrodes; and

a processor operably connected to the first and second electrodes of the catheter, the processor operable to collect conductance data from the device to determine a profile of the body lumen based upon the conductance data, the conductance data collected at a plurality of locations within the body lumen and determined at each of the plurality of locations when the first and second electrodes are immersed in a fluid within the body lumen, the processor further configured to calculate a cross-sectional area of the body lumen at each of the plurality of locations within the body lumen using the conductance data;

wherein the processor further comprises a computational program configured to detect a bifurcation in the body lumen based upon the conductance data obtained at the plurality of locations and changes in cross-sectional area identified using the conductance data, the conductance data including data obtained at the bifurcation using the device, and distinguishing the bifurcation from a lesion;

wherein the fluid within the body lumen comprises a first fluid having a first conductivity and a second fluid having a second conductivity; and

wherein the conductance data is determined at each of the plurality of locations when the first and second electrodes are immersed in each of the first fluid and the second fluid.

16. The system of claim 15, wherein:

the conductance data comprises a first conductance value determined at each of the plurality of locations when the first and second electrodes are immersed in the first fluid and a second conductance value determined at each of the plurality of locations when the first and second electrodes are immersed in the second fluid.

17. The system of claim 16, wherein:

the catheter further comprises a third electrode and a fourth electrode, wherein the first and third electrodes comprise excitation electrodes and the second and fourth electrodes comprise detection electrodes; and

the third and fourth electrodes are operably connected to the processor.

18. The system of claim 17, wherein:

the first and third electrodes are located between the proximal and distal ends of the catheter and the second and fourth electrodes are located between the first and third electrodes.

19. The system of claim 16, wherein the profile of the body lumen is determined from the first and second conductance values collected from each of the plurality of locations, the first conductivity of the first fluid, and the second conductivity of the second fluid.

20. A system comprising:

a device having a proximal end and a distal end, the distal end of the device configured for placement into a body lumen, the device comprising a first electrode and a second electrode located between the proximal and distal ends of the device; and

a processor operably connected to the first and second electrodes of the device, the processor operable to collect conductance data from the device to determine a profile of the body lumen based upon the conductance data, the conductance data collected at a plurality of locations within the body lumen and determined at each of the plurality of locations when the first and second electrodes are immersed in a fluid within the body lumen, the processor further configured to calculate a cross-sectional area of the body lumen at each of the plurality of locations within the body lumen using the conductance data;

wherein the processor further comprises a computational program configured to detect a bifurcation in the body lumen based upon the conductance data obtained at the plurality of locations and changes in cross-sectional area identified using the conductance data, the conductance data including data obtained at the bifurcation using the device, and distinguishing the bifurcation from a lesion, the computational program further configured to adjust the conductance data to eliminate a conductance spike due to the detection of a bifurcation;

wherein the fluid within the body lumen comprises a first fluid having a first conductivity and a second fluid having a second conductivity;

wherein the conductance data comprises a first conductance value determined at each of the plurality of locations when the first and second electrodes are immersed in the first fluid and a second conductance value determined at each of the plurality of locations when the first and second electrodes are immersed in the second fluid; and

wherein the profile of the body lumen is determined from the first and second conductance values collected from each of the plurality of locations, the first conductivity of the first fluid, and the second conductivity of the second fluid.