Assessment of pulmonary vascular resistance via pulmonary artery pressure
First Claim
1. A method of measuring pulmonary vascular resistance within a patient, the method comprising:
- electrically inducing a retrograde pressure pulse from the left atrium of the heart by using a pulse generator to electrically stimulate the heart to cause the mitral valve to be closed during atrial systole;
sensing at least one arterial pressure parameter in response to the retrograde pressure pulse using a pressure sensor located within a pulmonary artery of the patient; and
computing a value of the change in pulmonary vascular resistance using the at least one sensed arterial pressure parameter.
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Abstract
Methods and systems for assessing pulmonary or systemic vascular resistance in a patient using pressure measurements are disclosed. An illustrative method of measuring pulmonary vascular resistance includes electrically inducing a retrograde pressure pulse within the heart, sensing at least one arterial pressure parameter in response to the retrograde pressure pulse using a pressure sensor located within a pulmonary artery, and computing a value of the pulmonary vascular resistance using the at least one sensed arterial pressure parameter. Data from multiple pulmonary vascular resistance assessments can be taken over an extended period of time within the patient to aid in detecting an underlying cardiac or pulmonary condition such as cardiogenic pulmonary edema.
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Citations
22 Claims
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1. A method of measuring pulmonary vascular resistance within a patient, the method comprising:
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electrically inducing a retrograde pressure pulse from the left atrium of the heart by using a pulse generator to electrically stimulate the heart to cause the mitral valve to be closed during atrial systole; sensing at least one arterial pressure parameter in response to the retrograde pressure pulse using a pressure sensor located within a pulmonary artery of the patient; and computing a value of the change in pulmonary vascular resistance using the at least one sensed arterial pressure parameter. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A method of measuring pulmonary or systemic vascular resistance within a patient, the method comprising:
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electrically inducing a retrograde pressure pulse from an atrium of the heart by using a pulse generator to electrically stimulate the heart to cause the mitral valve to be closed during atrial systole; sensing at least one pressure parameter in response to the retrograde pressure pulse using a pressure sensor located within a body lumen of the patient; and computing a value of pulmonary or systemic vascular resistance using the at least one sensed pressure parameter.
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15. A system for measuring pulmonary vascular resistance within a patient, the system comprising:
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a pulse generator including at least one lead adapted to induce a retrograde pressure pulse from the left atrium of the heart by electrically stimulating the heart to cause the mitral valve to be closed during atrial systole; a pressure sensor adapted to sense an arterial pressure waveform within a pulmonary artery; and a processor adapted to compute a value of pulmonary vascular resistance in response to the retrograde pressure pulse based the sensed arterial pressure waveform. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22)
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Specification