Glycopegylated erythropoietin
First Claim
1. An erythropoietin peptide comprising a glycosyl linking group attached to an amino acid residue of said peptide, said glycosyl linking group comprising a modified sialyl residue having the formula:
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Accused Products
Abstract
The present invention provides conjugates between erythropoietin and PEG moieties. The conjugates are linked via an intact glycosyl linking group interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto a glycosyl residue on the peptide. Also provided are methods for preparing the conjugates, methods for treating various disease conditions with the conjugates, and pharmaceutical formulations including the conjugates.
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Citations
53 Claims
- 1. An erythropoietin peptide comprising a glycosyl linking group attached to an amino acid residue of said peptide, said glycosyl linking group comprising a modified sialyl residue having the formula:
- 26. An erythropoietin peptide comprising a glycosyl linking group attached to an amino acid residue of said peptide, said glycosyl linking group comprising a modified sialyl residue having the formula:
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49. An erythropoietin peptide comprising a glycosyl linking group attached to an amino acid residue of said peptide, said glycosyl linking group comprising a sialyl residue covalently linked to the moiety:
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50. An erythropoietin peptide comprising a glycosyl linking group attached to an amino acid residue of said peptide, said glycosyl linking group comprising a sialyl residue covalently linked to a member selected from:
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51. An erythropoietin peptide comprising a glycosyl linking group attached to an amino acid residue of said peptide, said glycosyl linking group comprising a sialyl residue covalently linked to a member selected from:
Specification