Piperidinyl derivative as a modulator of chemokine receptor activity

• US 8,633,226 B2
• Filed: 09/27/2012
• Issued: 01/21/2014
• Est. Priority Date: 06/25/2008
• Status: Active Grant

• Current Assignee: Bristol-Myers Squibb Company
• Original Assignee: Bristol-Myers Squibb Company
• Inventors: Santella, Joseph B.
• Primary Examiner(s): Wang, Shengjun
• Application Number:
  US13/628,180
• Publication Number:
  US 20130023564A1
• Time in Patent Office: 481 Days
• Field of Search: 514/327, 546/217
• US Class Current: 514/327
• CPC Class Codes: A61P 1/00 Drugs for disorders of the alimentary tract or the digestive system
• CPC Class Codes: A61P 1/04 for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
• CPC Class Codes: A61P 11/00 Drugs for disorders of the respiratory system
• CPC Class Codes: A61P 11/06 Antiasthmatics
• CPC Class Codes: A61P 13/12 of the kidneys
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 17/06 Antipsoriatics
• CPC Class Codes: A61P 19/00 Drugs for skeletal disorders
• CPC Class Codes: A61P 19/02 for joint disorders, e.g. arthritis, arthrosis
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/04 Centrally acting analgesics, e.g. opioids
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 31/18 for HIV
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 37/02 Immunomodulators
• CPC Class Codes: A61P 37/04 Immunostimulants
• CPC Class Codes: A61P 37/06 Immunosuppressants, e.g. drugs for graft rejection
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system
• CPC Class Codes: A61P 9/04 Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
• CPC Class Codes: A61P 9/10 : for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• CPC Class Codes: C07D 211/52 : having an aryl radical as the second substituent in position 4

Abstract

The present application describes the compound of formula (I):

or stereoisomers or pharmaceutically acceptable salts thereof. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and arthrosclerosis using the compound of the invention are disclosed.

Claims

1. A method for preparing a medicament for the treatment of inflammation comprising formulating the compound of Formula (I):

3. The method of claim 1 or 2, wherein the inflammation is associated with rheumatoid arthritis.

4. The method of claim 1 or 2, wherein inflammation is associated with fibrotic disease.

5. The method of claim 1 or 2, wherein the inflammation is associated with renal fibrosis.

6. The method of claim 1 or 2, wherein the inflammation is associated with cystic fibrosis.

7. The method of claim 1 or 2, wherein the inflammation is associated with interstitial lung diseases (ILD).

8. The method of claim 6, wherein the interstitial lung disease is idiopathic pulmonary fibrosis.

2. A method for preparing a medicament for the treatment of inflammation comprising formulating a composition of a compound of Formula (I):