Methods and compositions for treating anxiety

• US 8,633,233 B2
• Filed: 08/06/2009
• Issued: 01/21/2014
• Est. Priority Date: 08/06/2008
• Status: Active Grant

• Current Assignee: Hydra Biosciences, Inc.
• Original Assignee: Hydra Biosciences, Inc.
• Inventors: Chong, Jayhong, Fanger, Christopher, Moran, Magdalene M., Singer, Elisha, Strassmaier, Timothy, Ng, Howard
• Primary Examiner(s): Kim, Jennifer M
• Application Number:
  US13/057,527
• Publication Number:
  US 20110319417A1
• Time in Patent Office: 1,629 Days
• Field of Search: 514/245, 514/322, 514/375, 514/384
• US Class Current: 514/385
• CPC Class Codes: A61K 31/00 Medicinal preparations containing organic active ingredients
• CPC Class Codes: A61K 31/164 of a carboxylic acid with an aminoalcohol, e.g. ceramides
• CPC Class Codes: A61K 31/4184 condensed with carbocyclic rings, e.g. benzimidazoles
• CPC Class Codes: A61K 31/4196 1,2,4-Triazoles
• CPC Class Codes: A61K 31/423 condensed with carbocyclic rings
• CPC Class Codes: A61K 31/53 having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine melarsoprol A61K31/555 ; with four nitrogen atoms A61K31/495
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/08 Antiepileptics; Anticonvulsants
• CPC Class Codes: A61P 25/22 Anxiolytics
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: C07D 235/30 Nitrogen atoms not forming part of a nitro radical
• CPC Class Codes: C07D 251/16 to only one ring carbon atom
• CPC Class Codes: C07D 251/46 with oxygen or sulfur atoms attached to the two other ring carbon atoms
• CPC Class Codes: C07D 251/52 with an oxygen or sulfur atom attached to the third ring carbon atom
• CPC Class Codes: C07D 263/58 with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
• CPC Class Codes: C07D 405/14 containing three or more hetero rings
• CPC Class Codes: C07D 409/06 linked by a carbon chain containing only aliphatic carbon atoms
• CPC Class Codes: C07D 409/12 linked by a chain containing hetero atoms as chain links

Abstract

Methods of treating a TRPC5 mediated disorder in a subject by administering an effective amount of a TRPC5 antagonist, such as a compound disclosed herein, are described.

Claims

1. A method of treating anxiety in a subject, the method comprising administering an effective amount of a TRPC5 antagonist of formula (II), or a pharmaceutically acceptable salt thereof: