Methods and systems for optically characterizing a turbid material using a structured incident beam
First Claim
1. A method for optically characterizing a turbid sample, the method comprising:
- impinging a structured light beam on the sample, wherein the sample comprises an embedded region;
detecting a reflected light image of the structured light beam from the sample;
determining a measured reflectance image of the structured light beam for the sample based on the reflected light image and a reflectance standard;
determining an absorption coefficient μ
a, a scattering coefficient μ
s·
and/or an anisotropy factor g of the sample from the reflectance image;
estimating a size parameter of the embedded region based on the absorption coefficients μ
a, scattering coefficient μ
s and/or anisotropy factor g of the sample from the measured reflectance image;
wherein determining a measured reflectance image comprises the reflected light image of the sample normalized by a reflected light image of the reflectance standard; and
wherein the reflectance standard is a calibrated diffuse reflectance standard.
0 Assignments
0 Petitions
Accused Products
Abstract
Methods and systems for optically characterizing a turbid sample are provided. A structured light beam is impinged on the sample. The sample includes an embedded region. A reflected light image of the structured light beam is detected from the sample. A measured reflectance image of the structured light beam for the sample is determined based on the reflected light image and a reflectance standard. The following parameters are determined: absorption coefficients ÿa, scattering coefficient ÿs and anisotropy factor g of the sample from the reflectance image. A size parameter of the embedded region is estimated based on the absorption coefficients ÿa, scattering coefficient ÿs and/or anisotropy factor g of the sample from the measured reflectance image.
39 Citations
19 Claims
-
1. A method for optically characterizing a turbid sample, the method comprising:
-
impinging a structured light beam on the sample, wherein the sample comprises an embedded region; detecting a reflected light image of the structured light beam from the sample;
determining a measured reflectance image of the structured light beam for the sample based on the reflected light image and a reflectance standard;determining an absorption coefficient μ
a, a scattering coefficient μ
s·
and/or an anisotropy factor g of the sample from the reflectance image;estimating a size parameter of the embedded region based on the absorption coefficients μ
a, scattering coefficient μ
s and/or anisotropy factor g of the sample from the measured reflectance image;wherein determining a measured reflectance image comprises the reflected light image of the sample normalized by a reflected light image of the reflectance standard; and wherein the reflectance standard is a calibrated diffuse reflectance standard. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
-
-
10. A system for optically characterizing a turbid sample, the system comprising:
-
a structured light beam source configured to impinge a beam on a sample, wherein the sample comprises an embedded region; a detector configured to detect a reflected light image of the structured light beam from the sample; a signal analyzer configured to determine a measured reflectance image of the structured light beam for the sample based on the reflected light image of the sample normalized by another reflected light image of the reflectance standard, and to determine an absorption coefficient μ
a, scattering coefficient μ
s, and anisotropy factor g of the sample from the measured reflectance image, to estimate a size parameter of the embedded region based on the absorption coefficients μ
a, scattering coefficient μ
s, and/or anisotropy factor g of the sample from the measured reflectance image;wherein the signal analyzer is further configured to determine a measured reflectance image by normalizing the reflected light image of the sample by the reflected light image of the reflectance standard; and wherein the reflectance standard is a calibrated diffuse reflectance standard. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18)
-
-
19. A method for optically characterizing a turbid, biological tissue sample, the method comprising:
-
impinging a structured light beam on the tissue sample, wherein the tissue sample comprises an embedded region; detecting a reflected light image of the structured light beam from the tissue sample; determining a measured reflectance image of the structured light beam for the tissue sample based on the reflected light image of the sample normalized by a reflected light image of the reflectance standard, wherein the reflectance standard is a calibrated diffuse reflectance standard; determining an absorption coefficient μ
a, a scattering coefficient μ
s, and/or an anisotropy factor g of the tissue sample from the reflectance image;estimating a size parameter of the embedded region based on the absorption coefficients μ
a, scattering coefficient μ
s, and/or anisotropy factor g of the tissue sample from the measured reflectance image; andassessing a health parameter of the tissue sample based on the size parameter of the embedded region.
-
Specification