Application of electric fields to the lung as therapy for pulmonary edema
First Claim
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1. A device comprising:
- an electric field generator circuit configured to generate an electric field for application to a lung of a subject, the electric field being capable of modulating a level of fluid in the lung; and
a controller coupled to the electric field generator circuit and configured to control the electric field in the lung so as to use the electric field to modulate the level of fluid in the lung, wherein the controller is configured to apply the electric field to alveolar cells of the lung at an electric field level that is of sufficient magnitude to controllably effect removal by the alveolar cells of the fluid from the lung.
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Abstract
System and method of applying electric fields to a patient'"'"'s lung(s) to reduce pulmonary edema. The system includes a first electrode and a second electrode, at least one of which is associated with the lung. The electric field can be controlled so as to modulate a level of fluid in the lung.
18 Citations
20 Claims
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1. A device comprising:
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an electric field generator circuit configured to generate an electric field for application to a lung of a subject, the electric field being capable of modulating a level of fluid in the lung; and a controller coupled to the electric field generator circuit and configured to control the electric field in the lung so as to use the electric field to modulate the level of fluid in the lung, wherein the controller is configured to apply the electric field to alveolar cells of the lung at an electric field level that is of sufficient magnitude to controllably effect removal by the alveolar cells of the fluid from the lung. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A method comprising:
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generating and applying an electric field to a lung of a subject, the electric field being capable of modulating a level of fluid in the lung; and controlling the electric field to modulate the level of fluid in the lung, wherein controlling the electric field includes applying the electric field to alveolar cells of the lung at an electric field level that is of sufficient magnitude to modulate alveolar Na,K-ATPase activity to controllably effect removal by alveolar cells of the fluid from the lung. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17)
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18. A device-readable medium including instructions that, when performed by a device, cause the device to perform acts comprising:
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generating and applying an electric field to a lung of a subject, the electric field being capable of modulating a level of fluid in the lung; and controlling the electric field to modulate the level of fluid in the lung, wherein controlling the electric field includes applying the electric field to alveolar cells of the lung at an electric field level that is of sufficient magnitude to modulate Na,K-ATPase activity to controllably effect removal by alveolar cells of the fluid from the lung. - View Dependent Claims (19, 20)
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Specification