Dry powder inhaler and system for drug delivery
First Claim
1. An inhalation system for delivering a dry powder medicament to a pulmonary tract, comprising a dry powder inhaler configured to have at least two inlet apertures, wherein a first inlet aperture is in communication with a first air flow pathway and a second inlet aperture is in communication with a second air flow pathway, and the first airflow pathway and the second airflow pathway converge in a substantially perpendicular manner during an inhalation maneuver, and wherein said inhalation system has a total resistance to flow in a dosing configuration ranging in value from 0.065 to about 0.200 (√
- kPa)/liter per minute.
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Accused Products
Abstract
A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided. The dry powder inhaler can be provided with or without a unit dose cartridge for using with the inhaler. The inhaler and/or cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin and glucagon-like peptide 1 for the treatment of diabetes and/or obesity. The dry powder inhaler is compact; can be provided in various shapes and sizes, colors, and comprises a housing, a mouthpiece, a cartridge placement area, and a mechanism for opening and closing the medicament cartridge. The device is easy to manufacture, provides a pre-metered single unit dose, it is relatively easy to use, and can be reusable or disposable.
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Citations
21 Claims
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1. An inhalation system for delivering a dry powder medicament to a pulmonary tract, comprising a dry powder inhaler configured to have at least two inlet apertures, wherein a first inlet aperture is in communication with a first air flow pathway and a second inlet aperture is in communication with a second air flow pathway, and the first airflow pathway and the second airflow pathway converge in a substantially perpendicular manner during an inhalation maneuver, and wherein said inhalation system has a total resistance to flow in a dosing configuration ranging in value from 0.065 to about 0.200 (√
- kPa)/liter per minute.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. An inhalation system for delivering a dry powder medicament to a patient, comprising an inhaler comprising a container mounting area configured to receive a container, and a mouthpiece having at least two inlet apertures and at least one exit aperture;
- wherein a first inlet aperture of the at least two inlet apertures is in fluid communication with the container area, and a second inlet aperture of the at least two inlet apertures is in fluid communication with the at least one exit aperture via a flow path configured to bypass the container area and wherein the first inlet aperture and the second inlet aperture include flows that converge in a substantially perpendicular manner;
wherein the flow path configured to bypass the container area delivers 30% to 90% of a total flow going through the inhaler during an inhalation. - View Dependent Claims (16, 17)
- wherein a first inlet aperture of the at least two inlet apertures is in fluid communication with the container area, and a second inlet aperture of the at least two inlet apertures is in fluid communication with the at least one exit aperture via a flow path configured to bypass the container area and wherein the first inlet aperture and the second inlet aperture include flows that converge in a substantially perpendicular manner;
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18. An inhalation system for delivering a dry powder medicament to a patient, comprising a dry powder inhaler comprising a container region and a container;
- said dry powder inhaler and container combined are configured to have rigid flow conduits in a dosing configuration and a plurality of structural regions that provide a mechanisms for powder de-agglomeration of the inhalation system in use;
wherein at least one of the plurality of mechanisms for de-agglomeration is an agglomerate size exclusion aperture in the container region having a smallest dimension less than 3 mm;
said container comprising a top wherein the top and container are moveable relative to one another by a translational motion. - View Dependent Claims (20, 21)
- said dry powder inhaler and container combined are configured to have rigid flow conduits in a dosing configuration and a plurality of structural regions that provide a mechanisms for powder de-agglomeration of the inhalation system in use;
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19. An inhalation system for delivering a dry powder medicament to a patient, comprising a dry powder inhaler comprising a mouthpiece and a container;
- said dry powder inhaler and container combined are configured to have rigid flow conduits in a dosing configuration and a plurality of structural regions that provide a mechanisms for powder de-agglomeration of the inhalation system in use;
wherein at least one of the plurality of mechanisms for de-agglomeration is an air conduit configured in the mouthpiece which directs flow at an exit aperture in fluid communication with the container, said container comprising a top wherein the top and container are moveable relative to one another by a translational motion.
- said dry powder inhaler and container combined are configured to have rigid flow conduits in a dosing configuration and a plurality of structural regions that provide a mechanisms for powder de-agglomeration of the inhalation system in use;
Specification