Transdermal device containing microneedles
First Claim
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1. A microneedle assembly comprising:
- a support comprising a first outer surface and a second outer surface, the second outer surface having sections that are parallel and sections that are slanted relative to the first surface;
a plurality of microneedles projecting outwardly from the second outer surface of the support, the microneedles comprising a base, a tip and an exterior surface;
a pathway comprisingan aperture extending through the interior of the support between the first outer surface of the support and the second outer surface of the support;
a channel disposed on the exterior surface of the plurality of microneedles, the channel having a surface, the channel being in end-to-end alignment with at least a portion of the aperture to form a junction through which fluids may pass, the junction being formed in the plane of the slanted section of the second outer surface of the support proximate to the base of the microneedle; and
a first angle formed between the slanted section of the second outer surface and the surface of the channel, the first angle being greater than 90 degrees.
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Abstract
The present invention includes a microneedle assembly having a support that includes a first surface and a second surface, the second surface further including a slanted surface. A plurality of microneedles are provided which project outwardly from the second surface of the support. A pathway through the microneedle assembly is formed and includes an aperture extending between the first surface of the support and the second surface of the support, a channel disposed on the exterior surface of at least one microneedle, the channel having a surface, the channel being in alignment with at least a portion of the aperture to form a junction through which fluids may pass.
106 Citations
20 Claims
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1. A microneedle assembly comprising:
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a support comprising a first outer surface and a second outer surface, the second outer surface having sections that are parallel and sections that are slanted relative to the first surface; a plurality of microneedles projecting outwardly from the second outer surface of the support, the microneedles comprising a base, a tip and an exterior surface; a pathway comprising an aperture extending through the interior of the support between the first outer surface of the support and the second outer surface of the support; a channel disposed on the exterior surface of the plurality of microneedles, the channel having a surface, the channel being in end-to-end alignment with at least a portion of the aperture to form a junction through which fluids may pass, the junction being formed in the plane of the slanted section of the second outer surface of the support proximate to the base of the microneedle; and a first angle formed between the slanted section of the second outer surface and the surface of the channel, the first angle being greater than 90 degrees. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A transdermal drug delivery device comprising:
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(i) a microneedle assembly comprising, (a) a support comprising a first outer surface and a second outer surface, the second outer surface having sections that are parallel and sections that are slanted relative to the first outer surface; (b) a plurality of microneedles projecting outwardly from the second outer surface of the support, the microneedles comprising a base, a tip and an exterior surface; (c) fluidic pathways comprising a plurality of apertures extending through the interior of the support between the first outer surface of the support and the second outer surface of the support, at least one channel disposed on the exterior surface of at least one microneedle, the channel having a surface, the channel being in end-to-end alignment with at least a portion of one of said apertures to form a junction through which fluids may pass, the junction being formed in the plane of the slanted section of the second outer surface of the support proximate to the base of the microneedles wherein a first angle formed between the slanted section of the second surface and the surface of the channel is greater than 90 degrees; (ii) a drug delivery assembly comprising (a) a reservoir for holding a drug compound, (b) a rate control membrane that is in fluid communication with the reservoir positioned between the reservoir and the first outer surface of the support, and (iii) a release member that is impermeable to the drug compound and positioned adjacent to the rate control membrane of the drug delivery assembly and the first surface of the support of the microneedle assembly, wherein the release member is configured to be at least partially separated from the rate control membrane of the drug delivery assembly and the support of the microneedle assembly when drug delivery device is an active configuration. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20)
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Specification