Automatic injection device

• US 8,636,704 B2
• Filed: 04/29/2010
• Issued: 01/28/2014
• Est. Priority Date: 04/29/2009
• Status: Active Grant

• Current Assignee: AbbVie Biotechnology Ltd. (Puerto Rico) (Abbvie Incorporated)
• Original Assignee: AbbVie Biotechnology Ltd. (Puerto Rico) (Abbvie Incorporated)
• Inventors: Shang, Sherwin S., Ozdaryal, Esra, Plew, Marc M., Szechinski, William P.
• Primary Examiner(s): Sirmons, Kevin C
• Assistant Examiner(s): WILSON, LARRY ROSS
• Application Number:
  US12/770,557
• Publication Number:
  US 20110054414A1
• Time in Patent Office: 1,370 Days
• Field of Search: 604 68- 72, 604/131, 604134-136, 604/138, 604/141, 604/156, 604/157, 604/181, 604/187, 604/218, 604/220, 604/228
• US Class Current: 604/220
• CPC Class Codes: A61M 2005/206 With automatic needle insertion
• CPC Class Codes: A61M 2005/2073 preventing premature release, e.g. by making use of a safety lock
• CPC Class Codes: A61M 2205/584 having a color code
• CPC Class Codes: A61M 5/20 Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically A61M5/142 , A61M5/46 take precedence; hypodermic projectiles F42B12/54
• CPC Class Codes: A61M 5/2033 Spring-loaded one-shot injectors with or without automatic needle insertion multishot dosing syringes A61M5/31525, needle insertion only A61M5/3287
• CPC Class Codes: A61M 5/315 Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
• CPC Class Codes: A61M 5/31511 Piston or piston-rod constructions, e.g. connection of piston with piston-rod A61M5/5066 takes precedence
• CPC Class Codes: A61M 5/3157 Means providing feedback signals when administration is completed A61M5/20 takes precedence
• CPC Class Codes: A61M 5/31578 based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
• CPC Class Codes: A61M 5/3202 Devices for protection of the needle before use, e.g. caps A61M5/50 takes precedence; for infusion spikes A61M5/1626; protectors for sharps A61B50/3001
• CPC Class Codes: Y10T 29/49826 Assembling or joining

Abstract

Exemplary embodiments provide a syringe plunger formed of a polymeric material. The syringe plunger includes a pressurizer disposed at a proximal end, and a distal end bifurcated into a first plunger arm having a first conical surface and a second conical surface, and a second plunger arm having a first conical surface and a second conical surface. The distal end includes a first contact surface defined by the first conical surface of the first plunger arm and the first conical surface of the second plunger arm, the first contact surface configured to initially contact a firing engagement mechanism, the first contact surface disposed at a first angle of between about 40° and about 80° relative to a longitudinal axis of the syringe plunger. The distal end also includes a second contact surface defined by the second conical surface of the first plunger arm and the second conical surface of the second plunger arm, the second contact surface configured to contact the firing engagement mechanism subsequent to contact by the first contact surface.

Claims

1. A syringe plunger formed of a polymeric material, the syringe plunger comprising:

a pressurizer disposed at a proximal end; and

a distal end bifurcated into a first plunger arm having a first conical surface and a second conical surface, and a second plunger arm having a first conical surface and a second conical surface, the distal end including;

a first contact surface defined by the first conical surface of the first plunger arm and the first conical surface of the second plunger arm, the first contact surface configured to initially contact a firing engagement mechanism, the first contact surface disposed at a first angle of between about 40° and

about 80°

relative to a longitudinal axis of the syringe plunger, and

a second contact surface defined by the second conical surface of the first plunger arm and the second conical surface of the second plunger arm, the second contact surface configured to contact the firing engagement mechanism subsequent to contact by the first contact surface.

2. The syringe plunger of claim 1, wherein the firing engagement mechanism is configured to engage the first and second contact surfaces of the plunger arms, the firing engagement mechanism actuating the syringe plunger when the firing engagement mechanism is activated by a minimum force of between about 5 N and about 25 N.

3. The syringe plunger of claim 2, wherein, upon actuation of the syringe plunger, the pressurizer of the syringe plunger pressurizes a substance in a syringe barrel and causes the substance to be expelled from the syringe barrel.

4. The syringe plunger of claim 1, wherein the polymeric material of the syringe plunger has a flexural modulus of between about 2,000 MPa and about 5,500 MPa.

5. The syringe plunger of claim 1, wherein the first and second contact surfaces have a surface texture that is substantially rough.

6. The syringe plunger of claim 1, wherein the first and second contact surfaces have a surface texture that is substantially smooth.

7. The syringe plunger of claim 1, wherein the second contact surface is disposed at a second angle of about 6°

-38°

relative to the longitudinal axis of the syringe plunger.

8. The syringe plunger of claim 1, wherein the second contact surface is disposed at a second angle of about 8°

-25°

relative to the longitudinal axis of the syringe plunger.

9. The syringe plunger of claim 1, wherein the first and second plunger arms are separated by a third angle of between about 0.5°

and about 2.0°

.

10. The syringe plunger of claim 1, wherein the first and second plunger arms are separated by a distance of between about 2.55 mm and about 4.25 mm.

11. The syringe plunger of claim 1, wherein the first and second plunger arms are separated by a distance of about 3.05 mm.

12. The syringe plunger of claim 1, wherein the polymeric material is selected from the group consisting of thermoplastic materials and thermosetting materials.

13. The syringe plunger of claim 12, wherein the thermoplastic materials are selected from the group consisting of polyacetal, polycarbonate, polyacrylate, polyamide, polyester, acryonitrile-butadiene-styrene (ABS), polyvinyl chloride (PVC) and their copolymers, terpolymers, and filled composites thereof.

14. The syringe plunger of claim 13, wherein the polyacetal materials are selected from the group consisting of acetal homopolymers, copolymers, and filled materials thereof.

15. The syringe plunger of claim 14, wherein the filled materials are glass sphere filled or glass fiber filled.

16. The syringe plunger of claim 12, wherein the thermosetting materials are selected from the group consisting of epoxy, acrylic, urethane, ester, vinyl ester, epoxy-polyester, acrylic-urethane, and flurovinyl.

17. The syringe plunger of claim 16, wherein the acrylic material comprises a reactive functionality selected from the group consisting of an acid, a hydroxyl group, and an epoxy group.

18. The syringe plunger of claim 16, wherein the epoxy material comprises a reactive functionality that can be cured by a method selected from the group consisting of visible, ultraviolet and thermal crosslinking.

19. The syringe plunger of claim 12, wherein the thermosetting materials are selected from the group consisting of an epoxy homopolymer, copolymer or filled composite thereof.

20. The syringe plunger of claim 1, wherein the first contact surface has an open segment between the first and second plunger arms.

21. The syringe plunger of claim 1, wherein the first and second plunger arms have a mid point fixed configuration.

22. The syringe plunger of claim 1, wherein the first and second plunger arms have a top point fixed configuration.

23. An automatic injection device, comprising:

a syringe including a syringe barrel for holding a substance; and

a syringe plunger formed of a polymeric material, the syringe plunger including;

a pressurizer disposed at a proximal end; and

a distal end bifurcated into a first plunger arm having a first conical surface and a second conical surface, and a second plunger arm having a first conical surface and a second conical surface, the distal end including;

a first contact surface defined by the first conical surface of the first plunger arm and the first conical surface of the second plunger arm, the first contact surface configured to initially contact a firing engagement mechanism, the first contact surface disposed at a first angle of between about 40° and

about 80°

relative to a longitudinal axis of the syringe plunger, and

a second contact surface defined by the second conical surface of the first plunger arm and the second conical surface of the second plunger arm, the second contact surface configured to contact the firing engagement mechanism subsequent to contact by the first contact surface.

24. The automatic injection device of claim 23, further comprising:

the firing engagement mechanism configured to engage the first and second contact surfaces of the plunger arms, the firing engagement mechanism actuating the syringe plunger when the firing engagement mechanism is activated by a minimum force of between about 5 N and about 25 N.

25. The automatic injection device of claim 24, wherein, upon actuation of the syringe plunger, the pressurizer of the syringe plunger pressurizes the substance in the syringe barrel and causes the substance to be expelled from the syringe barrel.

26. The automatic injection device of claim 23, wherein the polymeric material of the syringe plunger has a flexural modulus of between about 2,000 MPa and about 5,500 MPa.

27. The automatic injection device of claim 23, wherein the first and second contact surfaces have a surface texture that is substantially rough.

28. The automatic injection device of claim 23, wherein the first and second contact surfaces have a surface texture that is substantially smooth.

29. The automatic injection device of claim 23, wherein the second contact surface is disposed at a second angle of about 6°

-38°

relative to the longitudinal axis of the syringe plunger.

30. The automatic injection device of claim 23, wherein the second contact surface is disposed at a second angle of about 8°

-25°

relative to the longitudinal axis of the syringe plunger.

31. The automatic injection device of claim 23, wherein the first and second plunger arms are separated by a third angle of between about 0.5°

and about 2.0°

.

32. The automatic injection device of claim 23, wherein the first and second plunger arms are separated by a distance of between about 2.55 mm and about 4.25 mm.

33. The automatic injection device of claim 23, wherein the first and second plunger arms are separated by a distance of about 3.05 mm.

34. The automatic injection device of claim 23, wherein the polymeric material is selected from the group consisting of thermoplastic materials and thermosetting materials.

35. The automatic injection device of claim 34, wherein the thermoplastic materials are selected from the group consisting of polyacetal, polycarbonate, polyacrylate, polyamide, polyester, acryonitrile-butadiene-styrene (ABS), polyvinyl chloride (PVC) and their copolymers, terpolymers, and filled composites thereof.

36. The automatic injection device of claim 35, wherein the polyacetal materials are selected from the group consisting of acetal homopolymers, copolymers, and filled materials thereof.

37. The automatic injection device of claim 36, wherein the filled materials are glass sphere filled or glass fiber filled.

38. The automatic injection device of claim 34, wherein the thermosetting materials are selected from the group consisting of epoxy, acrylic, urethane, ester, vinyl ester, epoxy-polyester, acrylic-urethane, and flurovinyl.

39. The automatic injection device of claim 38, wherein the acrylic material comprises a reactive functionality selected from the group consisting of an acid, a hydroxyl group, and an epoxy group.

40. The automatic injection device of claim 38, wherein the epoxy material comprises a reactive functionality that can be cured by a method selected from the group consisting of visible, ultraviolet and thermal crosslinking.

41. The automatic injection device of claim 34, wherein the thermosetting materials are selected from the group consisting of an epoxy homopolymer, copolymer or filled composite thereof.

42. The automatic injection device of claim 23, wherein the first contact surface has an open segment between the first and second plunger arms.

43. The automatic injection device of claim 23, wherein the first and second plunger arms have a top point fixed configuration.

44. The automatic injection device of claim 23, wherein the first and second plunger arms have a mid point fixed configuration.

45. A method of forming a syringe plunger for an automatic injection device, the method comprising:

forming a distal end of the syringe plunger, the distal end bifurcated into a first plunger arm having a first conical surface and a second conical surface, and a second plunger arm having a first conical surface and a second conical surface;

forming a first contact surface with the first conical surface of the first plunger arm and the first conical surface of the second plunger arm, the first contact surface configured to initially contact a firing engagement mechanism of the automatic injection device, the first contact surface disposed at a first angle of between about 40° and

about 80°

with respect to a longitudinal axis of the syringe plunger;

forming a second contact surface with the second conical surface of the first plunger arm and the second conical surface of the second plunger arm, the second contact surface configured to contact the firing engagement mechanism subsequent to contact by the first contact surface;

forming a proximal end of the syringe plunger; and

forming an intermediate portion of the syringe plunger between the distal end and the proximal end.

46. The method of claim 45, wherein the distal end of the syringe plunger cooperatively engages the firing engagement mechanism to engage the first and second contact surfaces of the plunger arms such that the minimum force required to actuate the syringe plunger by the firing engagement mechanism is between about 5 N and about 25 N.

47. The method of claim 45, further comprising:

forming the syringe plunger of a polymeric material that results in the syringe plunger having a flexural modulus of between about 2,000 MPa and about 5,500 MPa.

48. The method of claim 45, further comprising:

forming the second contact surface such that the second contact surface is disposed at a second angel of between about 6°

-38°

with respect to a longitudinal axis of the syringe plunger.

49. The method of claim 48, further comprising:

forming the second contact surface such that the second contact surface is disposed at a second angle of between about 8°

-25°

with respect to the longitudinal axis of the syringe plunger.

50. The method of claim 45, further comprising:

forming the first and second plunger arms spaced apart with an angular separation therebetween of between about 0.5° and

about 2.0°

.

51. The method of claim 45, further comprising:

forming the first and second plunger arms spaced apart with a separation distance therebetween of between about 2.55 mm and about 4.25 mm.

52. The method of claim 51, further comprising:

forming the first and second plunger arms spaced apart with the separation distance therebetween of about 3.05 mm.

53. The method of claim 45, further comprising:

forming the first contact surface with an open segment between the first and second plunger arms.

54. The method of claim 45, further comprising:

forming the first and second plunger arms with a top point fixed configuration.

55. The method of claim 45, further comprising:

forming the first and second plunger arms with a mid point fixed configuration.

56. The method of claim 45, further comprising:

varying one or more molding parameters to result in a minimum force to actuate the syringe plunger in the automatic injection device of between about 5 N and about 25 N.