Stabilized glucagon solutions and uses therefor
First Claim
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1. A method of treating a glucagon-responsive medical condition, comprising:
- providing an aqueous solution of glucagon at a pH of greater than about 9;
storing the solution in liquid form at a pH of greater than about 9 for at least three days at room temperature or higher without substantial aggregation of the glucagon; and
delivering at least a portion of the solution into a subject after the step of storing.
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Abstract
Stabilized glucagon solutions, methods of storing and using the stabilized glucagon solutions, and drug delivery devices containing the stabilized glucagon solutions. In some embodiments, the glucagon solutions may be alkaline, such as with a pH of at least about 9. The glucagon solutions may be resistant to aggregation of glucagon when the solutions are stored for a prolonged period, such as at least about three days, at room temperature and/or physiological temperature.
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20 Claims
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1. A method of treating a glucagon-responsive medical condition, comprising:
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providing an aqueous solution of glucagon at a pH of greater than about 9; storing the solution in liquid form at a pH of greater than about 9 for at least three days at room temperature or higher without substantial aggregation of the glucagon; and delivering at least a portion of the solution into a subject after the step of storing. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 19)
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14. A drug delivery system, comprising:
a drug delivery device including a container holding an aqueous solution of glucagon that has been stored in the container at a pH of greater than about 9 and at room temperature or higher for at least three days, the glucagon being substantially non-aggregated, the device also including an outlet through which the solution is configured to be driven from the container for delivery into a subject. - View Dependent Claims (15, 16, 17, 18, 20)
Specification