Temporarily stiffened mesh prostheses
First Claim
1. A surgical mesh prosthesis comprising a porous surgical woven or knitted mesh comprising a biocompatible material selected from the group consisting of polypropylene, polyesters and polyamides, said mesh formed into the configuration of a pouch for encapsulation of an implantable electronic device, whereby tissue ingrowth into said mesh stabilizes said implantable electronic device within said mesh, said surgical mesh coated with a biodegradable polymer coating, wherein said coating (i) temporarily imparts stiffness to said mesh to at least 1.1 times its uncoated stiffness, (ii) is disposed on said mesh without substantially altering the porosity thereof, (iii) biodegrades in the body of a patient to allow the mesh to revert substantially to its uncoated stiffness, (iv) has sufficient strength to hold said mesh in the form of said pouch once said coating is dried, cured or set, and (v) has a molecular weight of between 10,000 and 200,000 Dalton, said coating further comprising at least one drug miscible in said polymer coating selected from the group consisting of antimicrobial agents, anesthetics, analgesics, anti-fibrotic agents and leukotriene inhibitors.
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Accused Products
Abstract
The present invention relates to medical prostheses and methods of manufacturing those devices. In particular, the prostheses are temporarily stiffened meshes with particular coatings to provide initial stiffness and thereby permit easier surgical handling for treatment or reconstruction of soft tissue defects. Preferred embodiments include surgical meshes coated with one or more biodegradable polymers that can act as a stiffening agent by coating the filaments or fibers of the mesh to temporarily immobilize the contact points of those filaments or fibers and/or by increasing the stiffness of the mesh by at least 1.1 times its original stiffness. The devices of the invention can also provide relief from various post-operative complications associated with their implantation, insertion or surgical use. By including biologically active agents and/or drugs in the coating, the devices provide prophylaxis for and can alleviate side effects or complications associated with the surgery or use of prostheses in general.
186 Citations
25 Claims
- 1. A surgical mesh prosthesis comprising a porous surgical woven or knitted mesh comprising a biocompatible material selected from the group consisting of polypropylene, polyesters and polyamides, said mesh formed into the configuration of a pouch for encapsulation of an implantable electronic device, whereby tissue ingrowth into said mesh stabilizes said implantable electronic device within said mesh, said surgical mesh coated with a biodegradable polymer coating, wherein said coating (i) temporarily imparts stiffness to said mesh to at least 1.1 times its uncoated stiffness, (ii) is disposed on said mesh without substantially altering the porosity thereof, (iii) biodegrades in the body of a patient to allow the mesh to revert substantially to its uncoated stiffness, (iv) has sufficient strength to hold said mesh in the form of said pouch once said coating is dried, cured or set, and (v) has a molecular weight of between 10,000 and 200,000 Dalton, said coating further comprising at least one drug miscible in said polymer coating selected from the group consisting of antimicrobial agents, anesthetics, analgesics, anti-fibrotic agents and leukotriene inhibitors.
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21. A coated surgical mesh prosthesis comprising:
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a knit or woven porous surgical mesh formed of polypropylene filaments defining pores in said porous mesh bounded by said filaments and knots formed by said filaments, said knit surgical mesh having a stiffness; and a coating disposed on said filaments and said knots of said surgical mesh, said coating (i) comprises a tyrosine-derived polyarylate; (ii) comprises an antimicrobial agent; (iii) imparts to said mesh an enhanced stiffness at least 1.1 times its uncoated stiffness; and (iv) biodegrades in a physiological solution to allow the mesh to revert substantially to its uncoated stiffness, said pores in said coated surgical mesh having a size of between approximately 0.4 mm and approximately 3 mm. - View Dependent Claims (22, 23, 24, 25)
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Specification