Methods and devices to regulate stem cell homing
First Claim
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1. A device adapted to deliver donor cells with enhanced localization to host tissue including endothelial cells in a body, comprising:
- an implantable delivery device configured to deliver the donor cells to the lumen of a vessel in the body and having a lumen with a surface portion including activated endothelium applied to the surface portion which has ridges configured to promote interaction between the activated endothelium and the donor cells so as to enhance the localization, extravasation, or both, of the donor cells by activating adhesion molecules on the donor cells or increasing expression of adhesion molecules on the donor cells relative to donor cells in the absence of the activated endothelium and ridges.
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Abstract
A device for altering the expression or activation of adhesion molecules on cells including endothelial cells, as well as methods for altering the expression or activation of adhesion molecules on cells including endothelial cells, are provided.
76 Citations
23 Claims
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1. A device adapted to deliver donor cells with enhanced localization to host tissue including endothelial cells in a body, comprising:
an implantable delivery device configured to deliver the donor cells to the lumen of a vessel in the body and having a lumen with a surface portion including activated endothelium applied to the surface portion which has ridges configured to promote interaction between the activated endothelium and the donor cells so as to enhance the localization, extravasation, or both, of the donor cells by activating adhesion molecules on the donor cells or increasing expression of adhesion molecules on the donor cells relative to donor cells in the absence of the activated endothelium and ridges. - View Dependent Claims (2, 3, 4, 19, 20)
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5. A device for treating hematopoietic donor cells used in cell therapy, comprising:
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a surface portion; and an activation surface including different agents applied to the surface portion, wherein the different agents increase expression or activation of adhesion molecules on hematopoietic donor cells, the activation surface having ridges configured to promote interaction between the different agents and the hematopoietic donor cells as the hematopoietic donor cells contact the activation surface, wherein the activation surface comprises a plurality of activation surface regions each including one or more of the different agents, and wherein the activation surface regions are arranged to allow the hematopoietic donor cells to contact each of the activation surface regions with the different agents in a predetermined order to allow multiple steps of activation according to a predetermined activation sequence selected so as to increase expression or activated adhesion molecules including LFA-1 or Mac-1 on the hematopoietic donor cells. - View Dependent Claims (6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 21, 22)
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23. A device for treating progenitor donor cells used in cell therapy, comprising:
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a surface portion; and an activation surface including different agents applied to the surface portion, wherein the different agents increase expression or activation of adhesion molecules on progenitor donor cells, the activation surface having ridges configured to promote interaction between the different agents and the progenitor donor cells as the progenitor donor cells contact the activation surface, wherein the activation surface comprises a plurality of activation surface regions each including one or more of the different agents, and wherein the activation surface regions are arranged to allow the progenitor donor cells to contact each of the activation surface regions with the different agents in a predetermined order to allow multiple steps of activation according to a predetermined activation sequence selected so as to increase expression or activated adhesion molecules including LFA-1 or Mac-1 on the progenitor donor cells.
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Specification