Methods of antagonizing signal transduction in dorsal root ganglion cells
First Claim
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1. A method of antagonizing signal transduction in dorsal root ganglion cells in a subject, comprising administering to the subject a monoclonal antibody or antigen-binding fragment thereof that specifically binds to a polypeptide sequence of amino acid residues 27-164 of SEQ ID NO:
- 2, and wherein after administration the signal transduction induced by the polypeptide in the dorsal root ganglion cells is reduced.
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Abstract
Use of antagonists to IL-31 are used to treat inflammation and pain by inhibiting, preventing, reducing, minimizing, limiting or minimizing stimulation in neuronal tissues. Such antagonists include antibodies and fragments, derivative, or variants thereof. Symptoms such as pain, tingle, sensitization, tickle associated with neuropathies are ameliorated.
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13 Claims
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1. A method of antagonizing signal transduction in dorsal root ganglion cells in a subject, comprising administering to the subject a monoclonal antibody or antigen-binding fragment thereof that specifically binds to a polypeptide sequence of amino acid residues 27-164 of SEQ ID NO:
- 2, and wherein after administration the signal transduction induced by the polypeptide in the dorsal root ganglion cells is reduced.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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