Biocompatible scaffold for ligament or tendon repair
First Claim
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1. A tendon or ligament repair implant, comprising:
- a biocompatible scaffold; and
at least one minced tissue fragment derived from ligament tissue or tendon tissue, the at least one minced tissue fragment including an effective amount of viable cells that can migrate out of the minced tissue fragment and populate the scaffold, the at least one minced tissue fragment being associated with at least a portion of the scaffold; and
an autograft selected from the group consisting of ligament tissue, bone-patellar tendons, tendon-bone tendons, hamstring tendons, and iliotibial band;
wherein the scaffold and the autograft are configured in an orientation selected from the group consisting of the scaffold being placed around the autograft, the scaffold being surrounded by the autograft, and the scaffold being placed alongside the autograft.
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Abstract
A biocompatible ligament repair implant or scaffold device is provided for use in repairing a variety of ligament tissue injuries. The repair procedures may be conducted with ligament repair implants that contain a biological component that assists in healing or tissue repair. The biocompatible ligament repair implants include a biocompatible scaffold and particles of viable tissue derived from ligament tissue or tendon tissue, such that the tissue and the scaffold become associated. The particles of living tissue contain one or more viable cells that can migrate from the tissue and populate the scaffold.
298 Citations
25 Claims
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1. A tendon or ligament repair implant, comprising:
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a biocompatible scaffold; and at least one minced tissue fragment derived from ligament tissue or tendon tissue, the at least one minced tissue fragment including an effective amount of viable cells that can migrate out of the minced tissue fragment and populate the scaffold, the at least one minced tissue fragment being associated with at least a portion of the scaffold; and an autograft selected from the group consisting of ligament tissue, bone-patellar tendons, tendon-bone tendons, hamstring tendons, and iliotibial band; wherein the scaffold and the autograft are configured in an orientation selected from the group consisting of the scaffold being placed around the autograft, the scaffold being surrounded by the autograft, and the scaffold being placed alongside the autograft. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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25. A tendon or ligament repair implant, comprising:
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a biocompatible scaffold, wherein the scaffold comprises polymers or copolymers from monomers selected from the group consisting of lactide, glycolide, dioxanone, and caprolactone; and at least one minced tissue fragment derived from ligament tissue or tendon tissue, the at least one minced tissue fragment including an effective amount of viable cells that can migrate out of the minced tissue fragment and populate the scaffold, the at least one minced tissue fragment being associated with at least a portion of the scaffold; and an autograft selected from the group consisting of ligament tissue, bone-patellar tendons, tendon-bone tendons, hamstring tendons, and iliotibial band; wherein the scaffold and the autograft are configured in an orientation selected from the group consisting of the scaffold being placed around the autograft, the scaffold being surrounded by the autograft, and the scaffold being placed alongside the autograft.
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Specification