Manufacturing methods for covering endoluminal prostheses

• US 8,637,109 B2
• Filed: 12/02/2010
• Issued: 01/28/2014
• Est. Priority Date: 12/03/2009
• Status: Active Grant

• Current Assignee: Cook Medical Incorporated (Cook Group Incorporated)
• Original Assignee: Cook Medical Incorporated (Cook Group Incorporated)
• Inventors: Grewe, David, Roeder, Blayne, Charlebois, Steven, Griebel, Adam
• Primary Examiner(s): SELLMAN, CACHET I
• Application Number:
  US12/959,023
• Publication Number:
  US 20110135806A1
• Time in Patent Office: 1,153 Days
• Field of Search: 427/2.1, 427/2.24, 427/2.25, 427/282, 427/259, 427/462, 427/468, 427/458, 427/256, 425/72.2
• US Class Current: 427/2.1
• CPC Class Codes: B05D 1/007 using an electrostatic field B05D1/02 - B05D1/16 take precedence
• CPC Class Codes: D01D 5/0069 characterised by the spinning section, e.g. capillary tube, protrusion or pin
• CPC Class Codes: D01D 5/0076 characterised by the collecting device, e.g. drum, wheel, endless belt, plate or grid D01D5/0046 takes precedence

Abstract

The disclosure relates to a method for coating a target. The method includes providing a target and an electrospinning apparatus. The target comprises a first surface and an opposing second surface. The electrospinning apparatus comprises a mandrel, a mask including an aperture, a reservoir loaded with a solution, and an orifice fluidly coupled to the reservoir. The mandrel is located adjacent the target second surface. The orifice is located at a distance from the target first surface. The mask is located intermediate the orifice and the target first surface. The solution is electrospun through the mask aperture onto the target first surface. In one example the target is an endoluminal prosthesis.

Claims

1. A method for electrospinning comprising:

providing a target and an electrospinning apparatus;

the target comprising a first surface and an opposing second surface;

the electrospinning apparatus comprising a mandrel, a mask including an aperture, a reservoir loaded with a solution, an orifice fluidly coupled to the reservoir, an energy source electrically coupled to the orifice and the mandrel and further comprising applying a first electrical potential with the energy source between the orifice and the mandrel and a second electrical potential to the mask where the second electrical potential is less that the first electrical potential;

locating the mandrel adjacent the target second surface, locating the orifice at a distance from the target first surface, and locating the mask intermediate the orifice and the target first surface;

electrospinning the solution through the mask aperture onto the target first surface; and

where the first electrical potential is between about 10 kV and about 30 kV and the second electrical potential is between about 5 kV and about 18 kV.

2. The method of claim 1, where the distance between the orifice and the target first surface is between about 5 inches to about 8 inches.

3. The method of claim 2, where the distance between the orifice and the mask is between about 2 inches to about 4 inches.

4. The method of claim 1, further comprising moving the orifice relative to the target.

5. The method of claim 1, where the aperture comprises a shape selected from the group consisting of round, obround, polygonal, rectangular, square, freeform, or combinations thereof.

13. The method of claim 1, the mandrel comprising a material selected form the group consisting of metallic material and polymeric material.

14. The method of claim 1, the mandrel comprising a polytetrafluoroethy lene coating.

6. A method for preparing an endoluminal prosthesis comprising:

providing an endoluminal prosthesis and an electrospinning apparatus;

the endoluminal prosthesis defining an interior lumen with a proximal end, a distal end, a first surface and an opposing second surface;

the electrospinning apparatus comprising a mandrel, a mask including an aperture, a reservoir loaded with a solution, an orifice fluidly coupled to the reservoir, and an energy source electrically coupled to the orifice and the mandrel;

locating the mandrel at least partially within the endoluminal prosthesis lumen, locating the orifice at a distance from the endoluminal prosthesis first surface, and locating the mask intermediate the orifice and the endoluminal prosthesis first surface;

applying a first electrical potential with the energy source to the orifice and the mask, and grounding the mandrel;

applying a second electrical potential to the mask, where the second electrical potential is less than the first electrical potential;

electrospinning the solution through the mask aperture onto the endoluminal prosthesis first surface;

where the first electrical potential is between about 10 kV to about 30 kV and the second electrical potential is between about 5 kV to about 18 kV.

7. The method of claim 6, where the solution comprises at least one material selected from the group comprising polymers, proteins, and bioactive agents.

8. The method of claim 6, where the distance between the orifice and the endoluminal prosthesis first surface is between about 5 inches to about 8 inches.

9. The method of claim 8, where the distance between the orifice and the mask is between about 2 inches to about 4 inches.

10. The method of claim 6, further comprising moving the endoluminal prosthesis at least longitudinally relative to the orifice and further comprising electrospinning the solution about a longitudinal length of the endoluminal prosthesis.

11. The method of claim 6, further comprising moving the endoluminal prosthesis at least rotationally about an axis orthogonal to the orifice and further comprising electrospinning the solution about a circumferential length of the endoluminal prosthesis.

12. The method of claim 6, where the aperture comprises a shape selected from the group consisting of round, obround, polygonal, rectangular, square, freeform, or combinations thereof.

15. A method for preparing an endoluminal prosthesis comprising:

providing an endoluminal prosthesis and an electrospinning apparatus;

the endoluminal prosthesis defining an interior lumen with a proximal end, a distal end, a first surface and an opposing second surface;

the electrospinning apparatus comprising a mandrel, a mask including an aperture, a reservoir loaded with a solution, an orifice fluidly coupled to the reservoir, a ground plane, and an energy source electrically coupled to the orifice, the mandrel and the mask;

locating the mandrel at least partially within the endoluminal prosthesis lumen and adjacent the endoluminal prosthesis second surface, locating the orifice between about 5 inches to about 8 inches from the endoluminal prosthesis first surface, and locating the mask intermediate the orifice and the endoluminal prosthesis first surface and between about 2 inches to about 4 inches from the orifice;

applying a first electrical potential between about 10 kV to about 30 kV with the energy source to the orifice and a second electrical potential between about 5 kV to about 18 kV with the energy source to the mask;

grounding the mandrel and the ground plane;

moving the orifice relative to the endoluminal prosthesis;

electrospinning the solution through the mask aperture onto the endoluminal prosthesis first surface.