Method for determining at least one evaluation parameter of a blood sample

• US 8,637,320 B2
• Filed: 04/21/2010
• Issued: 01/28/2014
• Est. Priority Date: 03/24/2010
• Status: Active Grant

• Current Assignee: C. A. Casyso GmbH
• Original Assignee: C A Casyso AG
• Inventors: Schubert, Axel, Bels, Kevin
• Primary Examiner(s): SIEFKE, SAMUEL P
• Application Number:
  US12/764,611
• Publication Number:
  US 20110237913A1
• Time in Patent Office: 1,378 Days
• Field of Search: 436/68, 422/68.1, 422/500
• US Class Current: 436/68
• CPC Class Codes: A61B 5/01 Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue clinical contact thermometers G01K13/20
• CPC Class Codes: A61B 5/02035 Determining blood viscosity
• CPC Class Codes: A61B 5/1427 Multiple blood sampling, e.g. at periodic or pre-established intervals
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 5/150251 Collection chamber divided into at least two compartments, e.g. for division of samples injection syringes having more than one chamber A61M5/19; syringes for injection of two or more media A61M5/2448, A61M5/284; sample preparation for further analysis A61B5/150755
• CPC Class Codes: A61B 5/153 Devices specially adapted for taking samples of venous or arterial blood, e.g. with syringes
• CPC Class Codes: A61B 5/155 Devices specially adapted for continuous or multiple sampling, e.g. at predetermined intervals devices loaded with multiple lancets simultaneously A61B5/15146
• CPC Class Codes: A61B 5/157 Devices characterised by integrated means for measuring characteristics of blood
• CPC Class Codes: A61B 5/4821 Determining level or depth of anaesthesia A61B5/1106 takes precedence
• CPC Class Codes: G01N 33/49 Blood chemical methods for determining blood cell populations G01N33/5094; chemical analysis of blood groups or blood types G01N33/80
• CPC Class Codes: G01N 33/4905 Determining clotting time of blood by chemical methods G01N33/86, C12Q1/56
• CPC Class Codes: G16H 50/30 for calculating health indices; for individual health risk assessment
• CPC Class Codes: G16Z 99/00 Subject matter not provided for in other main groups of this subclass

Abstract

The present invention provides a method for determining at least one evaluation parameter of a blood sample, comprising the following steps: providing (S4) at least one blood gas parameter; providing (S5) at least one hemostasis parameter; and determining (S6 . . . S10″) the at least one evaluation parameter as a function of the blood gas parameter and/or the hemostasis parameter.

Claims

1. A method for determining at least one evaluation parameter of at least one blood sample, comprising:

providing at least one blood gas parameter;

providing at least one hemostasis parameter;

providing an interdependence parameter describing an interdependence between the blood gas parameter and the hemostasis parameter; and

determining the at least one evaluation parameter as a function of the blood gas parameter and the hemostasis parameter;

wherein determining the evaluation parameter comprises at least one of the following;

comparing the blood gas parameter with a blood gas parameter range and/or comparing the blood gas parameter with a blood gas parameter value;

wherein comparing the blood gas parameter with a blood gas parameter range and/or comparing the blood gas parameter with a blood gas parameter value is performed as a function of the interdependence parameter; and

wherein the interdependence parameter is provided by reading out a sensor, reading out a data input device and/or reading out a data storage.

2. The method according to claim 1, wherein the step of pro-viding the blood gas parameter comprises at least one of the following steps:

performing a blood gas analysis, measuring the blood gas parameter, reading out a sensor, reading out a data input device and/or reading out a data storage.

3. The method according to claim 1, wherein the blood gas parameter is selected from and/or is a function of at least one of a group of parameters, the group comprising:

a partial pressure of carbon dioxide, a partial pressure of oxygen, a partial pressure of nitrogen oxide, a pH-level, a base excess, a base deficit, hematocrit, a bicarbonate level, a concentration of lactate, a concentration of electrolytes, in particular calcium ions, a concentration of hemoglobin, a concentration of oxyhemoglobin, a concentration of carboxyhemoglobin and/or a concentration of methemoglobin.

4. The method according to claim 1, wherein the step of providing the hemostasis parameter comprises at least a one of the following steps:

performing a hemostasis analysis, measuring the hemostasis parameter, reading out a sensor, reading out a data input device and/or reading out a data storage.

5. The method according to claim 1, wherein the hemostasis parameter is a coagulation parameter or a clot lysis parameter.

6. The method according to claim 5, wherein the coagulation parameter is selected from and/or is a function of at least one of a group of parameters, the group comprising:

a clotting time, a clot formation time, a clot firmness, a maximum clot firmness, a fibrinogen functionality, a platelet functionality, an inhibitor functionality, in particular a protein C-level, a tissue factor passway inhibitor (TFPI)-level or an ATIII-level, and/or sample viscosity.

7. The method according to claim 1, further comprising the steps of:

providing a temperature parameter of the blood sample, a temperature parameter of a patient'"'"'s body and/or an expected temperature parameter of a patient'"'"'s body and determining the evaluation parameter also as a function of the temperature parameter.

8. The method according to claim 7, wherein the step of pro-viding the temperature parameter comprises at least a one of the following steps:

measuring the temperature parameter, reading out a sensor, reading out a data input device and/or reading out a data storage.

9. The method according to claim 7, wherein the step of determining the evaluation parameter comprises at least one of the following steps:

comparing the temperature parameter with a temperature parameter range and/or comparing the temperature parameter with a temperature parameter value.

10. The method according to claim 1, further comprising the step of providing an interdependence parameter describing an interdependence between at least two of a group of parameters, the group comprising:

the blood gas parameter, the hemostasis parameter and the temperature parameter.

11. The method according to claim 1, wherein the blood gas parameter range, the blood gas parameter value, the temperature parameter range, the temperature parameter value and/or the interdependence parameter is provided by calculating, estimating, measuring, reading out a sensor, reading out a data input device and/or reading out a data storage.

12. The method according to claim 10, wherein the step of comparing the blood gas parameter with a blood gas parameter range and/or comparing the blood gas parameter with a blood gas parameter value is performed as a function of the interdependence parameter.

13. The method according to claim 10, wherein the step of comparing the temperature parameter with a temperature parameter range and/or comparing the temperature parameter with a temperature parameter value is performed as a function of the interdependence parameter.

14. The method according to claim 1, wherein the hemostasis parameter is corrected as a function of the blood gas parameter and/or temperature parameter.

15. The method according to claim 14, wherein the blood gas parameter is corrected as a function of the hemostasis parameter and/or temperature parameter.

16. The method according to claim 14, wherein the evaluation parameter is determined as a function of the corrected hemostasis parameter and/or corrected blood gas parameter.

17. The method according to claim 1, wherein the hemostasis parameter, adapted hemostasis parameter, blood gas parameter and/or adapted blood gas parameter is transmitted to a data output device and/or output by a data output device as a function of the determined evaluation parameter.

18. The method according to claim 1, wherein the evaluation parameter is transmitted to a data output device and/or output by a data output device.

19. The method according to claim 1, wherein an output information and/or a control command for the data output device is selected from a plurality of output information and/or control commands as a function of the determined evaluation parameter.