Methods and devices for evaluating and treating a bone condition based on x-ray image analysis
First Claim
Patent Images
1. A method of treating a bone condition comprising (a) obtaining an image from a subject;
- (b) analyzing, using a computer system, the image obtained in step (a) to derive quantitative information on bone structure, wherein the quantitative information is obtained from a sliding region of interest (ROI) on the image;
(c) diagnosing a bone condition based on the analysis of step (b); and
(d) selecting and administering a suitable treatment to said subject based on said diagnosis.
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Abstract
This disclosure relates to methods and devices for analyzing x-ray images. Furthermore, bone condition of a subject can be evaluated by analyzing x-ray images of the subject'"'"'s bone from a sliding region of interest (ROI), e.g., an ROI that is moved on a pixel-by-pixel basis on the image, and therapies can then be selected or devised for the subject.
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Citations
27 Claims
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1. A method of treating a bone condition comprising (a) obtaining an image from a subject;
- (b) analyzing, using a computer system, the image obtained in step (a) to derive quantitative information on bone structure, wherein the quantitative information is obtained from a sliding region of interest (ROI) on the image;
(c) diagnosing a bone condition based on the analysis of step (b); and
(d) selecting and administering a suitable treatment to said subject based on said diagnosis. - View Dependent Claims (2, 3, 4, 5)
- (b) analyzing, using a computer system, the image obtained in step (a) to derive quantitative information on bone structure, wherein the quantitative information is obtained from a sliding region of interest (ROI) on the image;
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6. A method of determining bone mineral density from an x-ray image in a computer system, the method comprising the steps of
(a) determining density of one or more internal standards in said image; -
(b) creating a weighted mean between the values obtained in step (a); and (c) utilizing said weighted mean to determine bone mineral density of bone in a sliding ROI in said image. - View Dependent Claims (7)
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8. A method of determining bone structure from an x-ray image in a computer system comprising the steps of
(a) identifying one or more internal standards on said x-ray image; -
(b) determining the density or structure of said one or more standards; and (c) utilizing the density, structure or combinations thereof of said one or more standards to determine bone structure in a sliding ROI in the x-ray image. - View Dependent Claims (9)
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10. A method of evaluating, using a computer system, bone disease in a subject, the method comprising the steps of:
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(a) obtaining an x-ray image from said subject, wherein said image includes one or more bones; (b) assessing bone mineral density in at least one sliding ROI of said image; (c) assessing bone structure in said sliding ROI; and (d) combining said assessments of bone mineral density and bone structure to evaluate bone disease. - View Dependent Claims (11, 12, 13, 14, 15, 16)
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17. A method of treating bone disease in a subject, the method comprising the steps of:
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(a) obtaining an image from said subject, wherein said image includes one or more bones; (b) assessing, using a computer system, bone mineral density in at least one sliding ROI of said image; (c) assessing bone structure in said sliding ROI; (d) combining said assessments of bone mineral density and bone structure to evaluate bone disease; (e) selecting a therapy based on the evaluation of bone disease; and (f) administering said therapy to said subject. - View Dependent Claims (18, 19)
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20. A method for evaluating, using a computer system, bone disease in a subject, the method comprising the steps of:
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(a) obtaining an image of said subject wherein said image includes one or more bones; (b) assessing bone structure of said bone in a sliding ROI in said image; (c) assessing one or more macro-anatomical parameters in said image; and (d) combining the assessments bone structure and macro-anatomical parameter assessment to evaluate bone disease. - View Dependent Claims (21, 22, 23, 24, 25, 26, 27)
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Specification