Noninvasive eye-property monitoring, including aqueous-humor glucose monitoring as an indication of blood glucose level

• US 8,639,306 B2
• Filed: 02/04/2012
• Issued: 01/28/2014
• Est. Priority Date: 02/07/2011
• Status: Active Grant

• Current Assignee: Brien Holden Vision Diagnostics Incorporated
• Original Assignee: Brien Holden Vision Diagnostics Incorporated
• Inventors: Cornsweet, Tom N.
• Primary Examiner(s): WINAKUR, ERIC FRANK
• Application Number:
  US13/366,299
• Publication Number:
  US 20120215079A1
• Time in Patent Office: 724 Days
• Field of Search: 600/310, 600/316, 600/318, 600/319
• US Class Current: 600/319
• CPC Class Codes: A61B 5/14507 specially adapted for measuring characteristics of body fluids other than blood devices for taking samples of body liquids A61B10/0045
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/6821 Eye

Abstract

An eye-property monitoring system and method for performing the steps of (1) illuminating the eye from at least one light source whose wavelength interacts with internal eye properties in an optically active manner, (2) controlling, to make known and stable, the operating-power/light-output level of the source, (3) by such illuminating, producing light-source eye reflections including (a) multiple internal reflections within the outer structure of the eye, and (b) linked with those internal reflections at least one resulting outbound reflection, (4) monitoring the outbound-reflection to detect therein the reflection level associated with the at least one source, and (5) associating such detected reflection level as an indication of certain eye properties, such as aqueous glucose concentration.

Claims

1. An eye-property monitoring method comprising

in a seriatim manner, illuminating the eye from two or more, different-wavelength light sources whose respective wavelengths interact with internal eye properties in optically differentiated manners,

adjusting the operating levels of the sources to a predetermined relative setting,

by said illuminating, producing seriatim-light-source eye reflections including multiple internal reflections within the outer structure of the eye, and at least one resulting outbound reflection,

monitoring the outbound-reflection to detect therein the relative reflection levels associated with the sources, and

associating said detected, relative reflection levels with at least one eye property.

2. The method of claim 1 which further comprises (a) controlling the illuminating and adjusting steps with a computer, and (b) conducting the monitoring step with a computer.

3. The method of claim 1, wherein said illuminating is performed by directing light from the sources along a common illumination path which lies at an angle relative to the eye'"'"'s line of sight.

4. The method of claim 1, wherein said producing is accomplished to effect eye reflections occurring within the cornea of the eye.

5. The method of claim 1, wherein said producing is conducted so as to effect eye reflections including reflections from the optical interface existing between the cornea and the aqueous humor of the eye.

6. A blood glucose monitoring method comprising

in an alternating manner, illuminating the eye from two, different-wavelength light sources, one of which has a wavelength to which glucose is more optically active than it is to the wavelength of the other source,

adjusting the operating levels of the two sources to a predetermined relative setting,

by said illuminating, producing eye reflections including multiple internal reflections within the outer structure of the eye, and at least one resulting outbound reflection, and

monitoring a at least one condition of the outbound reflection and determining blood glucose level therefrom.

7. The method of claim 6 which further comprises (a) controlling the illuminating and adjusting steps with a computer, and (b) conducting the monitoring step with a computer.

8. The method of claim 6, wherein said illuminating is performed by directing light from the two sources along a common illumination path which lies at an angle relative to the eye'"'"'s line of sight.

9. The method of claim 6, wherein the two light sources are light-emitting diodes, and the two wavelengths are about 850- and about 540-nanometers.

10. The method of claim 6, wherein said alternating-manner illuminating is performed with a 50% duty cycle.

11. The method of claim 6, wherein said alternating is performed at a frequency of about 40Hz.

12. The method of claim 6, wherein said adjusting is performed to establish a constant, light-output-level relationship between the two sources.

13. The method of claim 6, wherein said producing is accomplished to effect eye reflections occurring within the cornea of the eye.

14. The method of claim 6, wherein said producing is conducted so as to effect eye reflections including reflections from the optical interface existing between the cornea and the aqueous humor of the eye.

15. An eye-property monitoring method comprising

illuminating the eye from at least one light source whose wavelength interacts with internal eye properties in an optically active manner,

controlling, to make substantially known and stable, at a predetermined setting, the operating-power/light-output level of the source,

by said illuminating, producing light-source eye reflections including (a) multiple internal reflections within the outer structure of the eye, and (b) at least one resulting outbound reflection,

monitoring the outbound-reflection to detect therein the reflection level associated with the at least one source, and

associating said detected reflection level with at least one certain eye property.

16. An eye-property monitoring system comprising

a light-source structure including a pair of light sources having different, respective wavelengths selected to interact with internal eye properties in optically differentiated manners, operable in a seriatim manner (a) to illuminate a person'"'"'s eye, and (b) to produce, by such illumination, eye reflections including (1) multiple internal reflections within the outer structure of the eye, and (2) at least one resulting outbound reflection,

an optical monitoring structure operatively associated with said light-source structure, disposed for monitoring said a resulting outbound-reflection to detect therein the relative reflection levels associated with said sources, and

a result-determining structure operatively connected to said optical monitoring structure for associating said detected, relative, outbound reflection levels with an indication of at least one eye property.

17. The system of claim 16 [which further comprises] said light source structure configured to provide illumination along a common incidence illumination path[along which said light sources illuminate the eye].

18. The system of claim 16, wherein said result-determining structure is also operatively connected to said light-source structure, and comprises an appropriately programmed digital computer which is operable to establish the operating light-output levels of said light sources.

19. An blood glucose monitoring system comprising

a pair of light sources having different, respective wavelengths one of which is more optically active with respect to glucose than is the other, said sources being operable in a seriatim manner (a) to illuminate a person'"'"'s eye, and (b) to produce, by such illumination, eye reflections including (1) multiple internal reflections within the outer structure of the eye, and (2) at least one resulting outbound reflection,

an optical monitoring structure operatively associated with said light-source structure, disposed for monitoring said resulting outbound-reflection to detect therein the relative reflection levels associated with said sources, and

a result-determining structure operatively connected to said optical monitoring structure for associating said detected, relative, outbound reflection levels with an indication of blood glucose level.

20. The system of claim 19 [which further comprises] said light source structure configured to provide illumination along a common incidence illumination path [along which said light sources illuminate the eye].

21. The system of claim 19, wherein said result-determining structure is also operatively connected to said light-source structure, and comprises an appropriately programmed digital computer which is operable to establish the operating light-output levels of said light sources.

22. An eye-property monitoring system comprising

at least one light source whose wavelength interacts with internal eye properties in an optically active manner, operable (a) to illuminate a person'"'"'s eye, and (b) to produce, by such illumination, eye reflections including (1) multiple internal reflections within the outer structure of the eye, and (2) at least one resulting outbound reflection,

an optical monitoring structure operatively associated with said at least one light source, disposed for monitoring said resulting outbound-reflection to detect therein the reflection level associated with the at least one source, and

a result-determining structure, operatively connected to said optical monitoring structure for associating said detected, resulting reflection level with an indication of at least one eye property.

23. The system of claim 22 [which further comprises] said light source structure configured to provide illumination along a common incidence illumination path [along which said light sources illuminate the eye].

24. The system of claim 22, wherein said result-determining structure is also operatively connected to said at least one light source, and comprises an appropriately programmed digital computer which is operable to establish the operating light-output level of the source.