System and method for electrically shielding a microelectrode array in a physiological pathway from electrical noise

• US 8,639,312 B2
• Filed: 12/10/2009
• Issued: 01/28/2014
• Est. Priority Date: 12/10/2008
• Status: Active Grant

• Current Assignee: University of Utah Research Foundation (State of Utah)
• Original Assignee: University of Utah Research Foundation (State of Utah)
• Inventors: Clark, Gregory Arthur, Warren, David J., Ledbetter, Noah M.
• Primary Examiner(s): Porter, Jr., Allen
• Application Number:
  US12/635,374
• Publication Number:
  US 20100161019A1
• Time in Patent Office: 1,510 Days
• Field of Search: 607116-118, 600/372, 600/373, 600/378, 600/383, 600/393, 600544-545, 600/546
• US Class Current: 600/378
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/0556 Cuff electrodes
• CPC Class Codes: A61N 1/086 Magnetic resonance imaging [MRI] compatible leads

Abstract

A system and method for electrically shielding a physiological pathway from electrical noise is disclosed. The method includes the operation of implanting at least one signal microelectrode into a patient such that the signal microelectrode is proximate to the physiological pathway. An additional operation includes substantially enclosing the microelectrode and a section of the physiological pathway with an electrical shielding wrap. The electrical shielding wrap includes a plurality of holes that enable fluid communication of physiological fluids between an inside and outside of the wrap.

Claims

1. An electrically shielded containment system used to substantially block electrical noise at a physiological pathway in a conductive complex physiological solution, comprising:

an array of signal microelectrodes configured to penetrate the physiological pathway and being operable for implantation in the physiological pathway wherein each signal microelectrode of the array is perpendicular to and integrated on a dielectric substrate; and

wherein each microelectrode of the array is substantially coated with an insulative material to reduce the level of electrical noise received by each microelectrode and wherein each microelectrode of the array has exposed insulated tips; and

wherein the array of signal microelectrodes include at least one reference microelectrode located adjacent to and integrated with the microelectrodes on the dielectric substrate, wherein the at least one reference microelectrode is positioned on the dielectric substrate relative to the signal microelectrodes to enable a reduced level of electrical noise to be detected between the at least one reference microelectrode and the signal microelectrodes; and

wherein each of the at least one reference microelectrode has a greater exposed uninsulated surface area relative to the exposed tips of each of the signal microelectrodes; and

an electrical shielding wrap configured to substantially enclose the array of signal microelectrodes and the physiological pathway sufficient to act as a barrier of undesired electrical signals, wherein the electrical shielding wrap is of a porous material and includes a plurality of holes that enable fluid communication of physiological fluids between an inside and outside of the wrap and that enable normal physiological processes to occur.

2. The system of claim 1, wherein the electrical shielding wrap is coated with an insulative material to reduce short circuiting between the electrical shielding wrap and the array of signal microelectrodes.

3. The system of claim 1, wherein the physiological pathway is selected from the group consisting of a single nerve fiber, a nerve bundle, a muscle fiber, and a muscle fiber bundle.

4. The system of claim 1, wherein the array of signal microelectrodes is completely enclosed within the electrical shielding wrap.

5. The system of claim 1, further comprising at least one wire electrically coupled to the array of signal microelectrodes and directed through one of the plurality of holes or through ends of the electrical shielding wrap to enable the array of signal microelectrodes to be connected to at least one of a remote power system and a wireless communication system.

6. The system of claim 1, further comprising at least one of a remote power system and a wireless communication system integrated with the array of signal microelectrodes.

7. The system of claim 6, further comprising an inductive coupling power source configured to provide power to the remote power system integrated with the array of signal microelectrodes.

8. The system of claim 6, wherein the wireless communication system is configured to provide full duplex wireless communication with the array of signal microelectrodes.

9. The system of claim 1, further comprising at least one wire electrically coupled to the array of signal microelectrodes and directed through one of the plurality of holes or through ends of the electrical shielding wrap to enable the array of signal microelectrodes to be connected to at least one of a remote power system and a wired communication system.

10. The system of claim 1, wherein the electrical shielding wrap including the plurality of holes includes a substantially conductive biocompatible mesh material.

11. The system of claim 1, wherein the electrical shielding wrap is oriented between the array of signal microelectrodes and a source of undesirable electrical signals.

12. The system of claim 1, wherein each signal microelectrode in the array is individually addressable.

13. The system of claim 1, wherein the physiological pathway is a single nerve fiber or a nerve bundle.

14. A method of electrically shielding a physiological pathway to substantially block electrical noise from the physiological pathway in a conductive complex physiological solution, comprising:

implanting an array of signal microelectrodes into a patient such that the array of signal microelectrodes is proximate to the physiological pathway,

wherein each signal microelectrode of the array is perpendicular to and integrated on a dielectric substrate; and

wherein each microelectrode of the array is substantially coated with an insulative material to reduce the level of electrical noise received by each microelectrode and wherein each microelectrode of the array has exposed insulated tips; and

wherein the array of signal microelectrodes include at least one reference microelectrode located adjacent to and integrated with the microelectrodes on the dielectric substrate, wherein the at least one reference microelectrode is positioned on the dielectric substrate relative to the signal microelectrodes to enable a reduced level of electrical noise to be detected between the at least one reference microelectrode and the signal microelectrodes; and

wherein each of the at least one reference microelectrode has a greater exposed uninsulated surface area relative to the exposed tips of each of the signal microelectrodes; and

substantially electrically shielding the array of signal microelectrodes and a section of the physiological pathway from undesirable electrical signals with an electrical shielding wrap, wherein the electrical shielding wrap is of a porous material and includes a plurality of holes that enable fluid communication of physiological fluids between an inside and an outside of the wrap and that enable normal physiological processes to occur.

15. The method of claim 14, further comprising electrically connecting the array of signal microelectrodes with at least one of a remote power system and a wireless communication system located outside the electrical shielding wrap.

16. The method of claim 15, further comprising electrically connecting the array of signal microelectrodes with at least one of the remote power system and the wireless communication system using at least one wire to connect the remote power system and the wireless communication system, wherein the wire is fed through one of the plurality of holes or through openings at either end of the electrical shielding wrap.

17. The method of claim 15, wherein electrically connecting the array of signal microelectrodes further comprises electrically connecting the array of signal microelectrodes with at least one of the remote power system and the wireless communication system, wherein at least one of the remote power system and the wireless communication system are integrated with the array of signal microelectrodes and directed through an opening in the electrical shielding wrap to enable at least one of the remote power system and the wireless communication system to be electrically communicative with a source outside the electrical shielding wrap.

18. The method of claim 14, further comprising securing the electrical shielding wrap in place using a biologically compatible adhesive and/or a mechanical interlock.

19. The method of claim 14, wherein the electrically shielding includes enclosing the portion of the physiological pathway with the electrical shielding wrap.

20. The method of claim 14, further comprising electrically coupling at least one wire to the array of signal microelectrodes and directed through one of the plurality of holes or through ends of the electrical shielding wrap to enable the array of signal microelectrodes to be connected to at least one of a remote power system and a wired communication system.

21. The method of claim 14, wherein each signal microelectrode in the array is individually addressable.

22. The method of claim 14, wherein the physiological pathway is a single nerve fiber or a nerve bundle.