Nerve signal differentiation in cardiac therapy
First Claim
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1. A method of delivering therapy, wherein the method comprises:
- monitoring physiological parameters of a patient, wherein the physiological parameters comprise electrical activity of the patient'"'"'s vagus nerve;
determining whether the monitored electrical activity of the patient'"'"'s vagus nerve comprises efferent activity;
analyzing the monitored physiological parameters, wherein analyzing the monitored physiological parameters comprises determining whether the efferent activity of the electrical activity of the patient'"'"'s vagus nerve is reduced over time; and
initiating or adjusting non-nerve stimulating cardiac therapy if the efferent activity of the electrical activity of the patient'"'"'s vagus nerve is reduced, wherein the non-nerve stimulating cardiac therapy comprises at least one of pacing therapy, cardiac resynchronization therapy, anti-tachycardia pacing, high-energy shock pulses for cardioversion/defibrillation therapy, bradycardia pacing, and drug therapy, wherein the method further comprises determining whether the monitored electrical activity of the patient'"'"'s vagus nerve comprises afferent activity, and wherein determining whether the efferent activity of the electrical activity of the patient'"'"'s vagus nerve is reduced comprises comparing the efferent activity to the afferent activity.
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Abstract
Methods of nerve signal differentiation, methods of delivering therapy using such nerve signal differentiation, and to systems and devices for performing such methods. Nerve signal differentiation may include locating two electrodes proximate nerve tissue and differentiating between efferent and afferent components of nerve signals monitored using the two electrodes.
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Citations
9 Claims
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1. A method of delivering therapy, wherein the method comprises:
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monitoring physiological parameters of a patient, wherein the physiological parameters comprise electrical activity of the patient'"'"'s vagus nerve; determining whether the monitored electrical activity of the patient'"'"'s vagus nerve comprises efferent activity; analyzing the monitored physiological parameters, wherein analyzing the monitored physiological parameters comprises determining whether the efferent activity of the electrical activity of the patient'"'"'s vagus nerve is reduced over time; and initiating or adjusting non-nerve stimulating cardiac therapy if the efferent activity of the electrical activity of the patient'"'"'s vagus nerve is reduced, wherein the non-nerve stimulating cardiac therapy comprises at least one of pacing therapy, cardiac resynchronization therapy, anti-tachycardia pacing, high-energy shock pulses for cardioversion/defibrillation therapy, bradycardia pacing, and drug therapy, wherein the method further comprises determining whether the monitored electrical activity of the patient'"'"'s vagus nerve comprises afferent activity, and wherein determining whether the efferent activity of the electrical activity of the patient'"'"'s vagus nerve is reduced comprises comparing the efferent activity to the afferent activity. - View Dependent Claims (6, 7, 8, 9)
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2. A method of delivering therapy, wherein the method comprises:
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monitoring physiological parameters of a patient, wherein the physiological parameters comprise electrical activity of the patient'"'"'s vagus nerve; determining whether the monitored electrical activity of the patient'"'"'s vagus nerve comprises efferent activity; analyzing the monitored physiological parameters, wherein analyzing the monitored physiological parameters comprises determining whether the efferent activity of the electrical activity of the patient'"'"'s vagus nerve is reduced over time; and initiating or adjusting non-nerve stimulating cardiac therapy if the efferent activity of the electrical activity of the patient'"'"'s vagus nerve is reduced, wherein the non-nerve stimulating cardiac therapy comprises at least one of pacing therapy, cardiac resynchronization therapy, anti-tachycardia pacing, high-energy shock pulses for cardioversion/defibrillation therapy, bradycardia pacing, and drug therapy, wherein determining whether the efferent activity of the electrical activity of the patient'"'"'s vagus nerve is reduced comprises comparing the average amplitude of a selected frequency range of the efferent activity to a selected value.
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3. A method of delivering therapy, wherein the method comprises:
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monitoring physiological parameters of a patient, wherein the physiological parameters comprise electrical activity of the patient'"'"'s vagus nerve; determining whether the monitored electrical activity of the patient'"'"'s vagus nerve comprises efferent activity; analyzing the monitored physiological parameters, wherein analyzing the monitored physiological parameters comprises determining whether the efferent activity of the electrical activity of the patient'"'"'s vagus nerve is reduced over time; and
initiating or adjusting non-nerve stimulating cardiac therapy if the efferent activity of the electrical activity of the patient'"'"'s vagus nerve is reduced, wherein the non-nerve stimulating cardiac therapy comprises at least one of pacing therapy, cardiac resynchronization therapy, anti-tachycardia pacing, high-energy shock pulses for cardioversion/defibrillation therapy, bradycardia pacing, and drug therapy, wherein determining whether the efferent activity of the electrical activity of the patient'"'"'s vagus nerve is reduced comprises comparing the average amplitude of a selected frequency range of the presently-monitored efferent activity to the average amplitude of the selected frequency range of previously-monitored efferent activity.
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4. A method of delivering therapy, wherein the method comprises:
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monitoring physiological parameters of a patient, wherein the physiological parameters comprise electrical activity of the patient'"'"'s vagus nerve; determining whether the monitored electrical activity of the patient'"'"'s vagus nerve comprises efferent activity; analyzing the monitored physiological parameters, wherein analyzing the monitored physiological parameters comprises determining whether the efferent activity of the electrical activity of the patient'"'"'s vagus nerve is reduced over time; and initiating or adjusting non-nerve stimulating cardiac therapy if the efferent activity of the electrical activity of the patient'"'"'s vagus nerve is reduced, wherein the non-nerve stimulating cardiac therapy comprises at least one of pacing therapy, cardiac resynchronization therapy, anti-tachycardia pacing, high-energy shock pulses for cardioversion/defibrillation therapy, bradycardia pacing, and drug therapy, wherein determining whether the efferent activity of the electrical activity of the patient'"'"'s vagus nerve is reduced comprises comparing the average power of a selected frequency range of the efferent activity to a selected value.
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5. A method of delivering therapy, wherein the method comprises:
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monitoring physiological parameters of a patient, wherein the physiological parameters comprise electrical activity of the patient'"'"'s vagus nerve; determining whether the monitored electrical activity of the patient'"'"'s vagus nerve comprises efferent activity; analyzing the monitored physiological parameters, wherein analyzing the monitored physiological parameters comprises determining whether the efferent activity of the electrical activity of the patient'"'"'s vagus nerve is reduced over time; and initiating or adjusting non-nerve stimulating cardiac therapy if the efferent activity of the electrical activity of the patient'"'"'s vagus nerve is reduced, wherein the non-nerve stimulating cardiac therapy comprises at least one of pacing therapy, cardiac resynchronization therapy, anti-tachycardia pacing, high-energy shock pulses for cardioversion/defibrillation therapy, bradycardia pacing, and drug therapy, wherein determining whether the efferent activity of the electrical activity of the patient'"'"'s vagus nerve is reduced comprises comparing the average power of a selected frequency range of the presently-monitored efferent activity to the average power of the selected frequency range of previously-monitored efferent activity.
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Specification