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Method and device for predicting abnormal medical events and/or assisting in diagnosis and/or monitoring, particularly in order to determine depth of anesthesia

  • US 8,641,632 B2
  • Filed: 11/03/2005
  • Issued: 02/04/2014
  • Est. Priority Date: 11/03/2004
  • Status: Active Grant
First Claim
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1. A method for predicting abnormal medical events, assisting in diagnosis, or monitoring a patient, comprising detecting and simultaneously distinguishing between, continuously and in real time, a concomitant occurrence of a temporary inefficiency of the cardiac baro-reflex and an activation of the non-baro-reflex cardiovascular regulation, wherein the detecting and simultaneously distinguishing is carried out using a device comprising a computing unit;

  • andwherein the detecting and simultaneous distinguishing comprises;

    a) continuously measuring (beat-by-beat) time intervals determined from an ECG between two consecutive cardiac cycles (IT) and arterial pressure (AP); and

    b) filtering by means of a low-pass filter the beat-by-beat series of the time intervals IT and the series of AP calculated at step a), the filtering giving rise to filtered series ITf and APf of IT and of AP respectively; and

    c) monitoring for the occurrence of one or more of the following sequences;

    (i) increase in APf/time period/reduced increase in ITf;

    (ii) increase in APf/time period/delayed increase in ITf; and

    (iii) increase in APf/time period/decrease in ITf;

    wherein the occurrence of any one of (i)-(iii) is a predictive index that indicates (a) the concomitant occurrence of a temporary inefficiency of the cardiac baro-reflex and an activation of the non-baro-reflex cardiovascular regulation and (b) the cardiovascular depth of anesthesia.

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