Method and device to treat kidney disease

• US 8,641,659 B2
• Filed: 02/17/2012
• Issued: 02/04/2014
• Est. Priority Date: 02/17/2011
• Status: Active Grant

• Current Assignee: Mozarc Medical US LLC
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Soykan, Orhan, Schu, Carl, Chaffin, Kimberly
• Primary Examiner(s): Mendez, Manuel
• Assistant Examiner(s): Eisenberg, Rebecca E
• Application Number:
  US13/399,910
• Publication Number:
  US 20120220926A1
• Time in Patent Office: 718 Days
• Field of Search: 604 27- 29
• US Class Current: 604/29
• CPC Class Codes: A61M 1/1678 intracorporal peritoneal dialysis A61M1/28
• CPC Class Codes: A61M 1/1696 with dialysate regeneration
• CPC Class Codes: A61M 1/28 Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
• CPC Class Codes: A61M 1/284 Continuous flow peritoneal dialysis [CFPD]
• CPC Class Codes: A61M 2205/04 implanted

Abstract

The invention relates to a method and device for dialysis and or bulk fluid removal by generating a fibrosis chamber within a body cavity and performing dialysis or bulk fluid removal. An implantable medical device is described having a fibrosis chamber and a pump. A dialysis chamber and an optional electrodialysis unit can further be provided. An additional controller uses sensory feedback to regulate the fluid levels by altering the extracellular fluid retention within the fibrosis chamber. This device can be used for the treatment of patients with chronic kidney disease who may also be suffering from cardiorenal syndrome and hypertension.

Claims

1. A medical device, comprising:

a partially porous mesh that forms a fibrosis cage upon implantation into a patient, the fibrosis cage defining a space for accessing fluid from the patient;

a pumping means for pumping fluid into and out of the fibrosis cage; and

a dialysis chamber for dialyzing the fluid from the patient having an inlet and an outlet for the movement of a dialysate through the dialysis chamber;

wherein the dialysis chamber may be located either extracorporeally with respect to the patient or intracorporeally with respect to the patient.

2. The medical device of claim 1, wherein one side of the partially porous mesh has a porous opening.

3. The medical device of claim 1, further comprising a material impermeable to cells surrounding the partially porous mesh.

4. The medical device of claim 1, wherein the pumping means is one selected from the group consisting of a bellows pump, a peristaltic pump, a pulsatile pump, an impeller pump, and a syringe pump, said pumping means positioned inside the partially porous mesh, outside the partially porous mesh or adjacent to the partially porous mesh.

5. The medical device of claim 1, wherein the pumping means is regulated to not exceed a maximum pressure difference of any one of 5, 15, 20, 25, 30, 35, 40, 45 and 50 mmHg, wherein the pressure difference is a pressure difference between the inside of the fibrosis cage and a peritoneal cage of a patient.

6. The medical device of claim 1, further comprising a catheter to convey fluid inside the dialysis chamber to the urinary bladder of a patient.

7. The medical device of claim 1, further comprising a controller for regulating the fluid volume of the patent and adjusting a clearance rate of the patient.

8. The medical device of claim 1, further comprising a means for sensing a fluid volume of the patient, wherein the means for sensing fluid volume is an electrical impedance plethysmography or an arterial pressure measurement.

9. The medical device of claim 1, further comprising one or more selected from the group consisting of an external dialysate cleansing unit containing a sorbent capable of removing waste components and ions from the dialysate or an electrodialyzer in fluid communication with the dialysis chamber for regenerating the dialysate.

10. The medical device of claim 1, further comprising a means for delivering a fresh dialysate to the dialysis chamber.

11. A medical device, comprising:

a partially porous mesh that forms a fibrosis cage upon implantation into a patient, and a pumping means for pumping fluid into and out of the fibrosis cage, wherein at least part of the fluid pumped into the fibrosis cage is removed from the patient, further comprising a catheter configured to discharge at least part of the fluid pumped into the fibrosis cage to the urinary bladder of the patient and wherein the medical device further comprises one or more piezoelectric vibrators to reduce or to remove calcification from the catheter.

12. The medical device of claim 11, wherein the pumping means is one selected from the group consisting of a bellows pump, a peristaltic pump, pulsatile pump and a syringe pump, said pumping means positioned inside the partially porous mesh, outside the partially porous mesh or adjacent to the partially porous mesh.

13. The medical device of claim 11, wherein the pumping means is regulated to not exceed a maximum pressure change of any one of 5, 15, 20, 25, 30, 35, 40, 45 and 50 mmHg, wherein the pressure difference is a pressure difference between the inside of the fibrosis cage and a peritonea cavity of the patient.

14. The medical system of claim 11, wherein the medical device is powered by any selected from the group consisting of an internal battery, an externally coupled power source and a rechargeable battery wherein the rechargeable battery is rechargeable by wireless energy transfer.